Dog gastric lipase

Dog gastric lipase CaMV enhanced 35S promoter/ CaMV 35S terminator LP of rabbit gastric lipase precursor LP of sweet potato sporamin precursor N. tabacum (leaves secretion) N. tabacum (leaves vacuole) 7% of acid extractable proteins 5% of acid extractable proteins 51... 

C. (2002) Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor. ). Biol. 

Dog gastric lipase Stimulation of its secretion in vivo and cytolocalization in mucous pit cells. Gastroenterology 102, 1535-1545. 

A., Verger, R., Doherty, A., Merot, B. and Danzin, C. (2001) Large-scale production of a therapeutic protein in transgenic tobacco plants effect of subcellular targeting on quality of a recombinant dog gastric lipase. Molecular Breeding 7, 329-340. 

Corn seed-derived dog gastric lipase as replacement of porcine-derived Pancrelipase... 

Corn seed-derived dog gastric lipase is under development by Meristem Therapeutics for the treatment of gastric lipase deficiency (steatorrhea), neonatal deficient pancreatic function, or when pancreatic function is compromised by diseases such as cystic fibrosis or chronic alcoholism [159]. The absence of gastric lipase in steatorrhea patients prevents the digestion of food lipids. Pre-term infants have difficulty digesting lipids and, unless they are breast-fed, have no access to this enzyme. 

Miled, N., Roussel, A., Bussetta, C., Berti-Dupuis, L, Riviere, M., Buono, G., Verger, R., Cambillau, C. and Canaan, S. (2003) Inhibition of dog and human gastric lipases by enantiomeric phosphonate inhibitors a structure-activity study. Biochemistry 42, 11587-11593... 

The optimum pH of gastric hpase was originally thought to be about pH 5.0 (14), but later work has shown that it may depend on the substrate and on the species. Thus the optimum pH range for hydrolysis of tripropionin or tributyrin by gastric lipase is 5.5-5.8, but 7.2-7.9 for hydrolysis of trilaurin or tristearin (243). Addition of calcium salts shifts the pH optimum for trilaurin or tristearin hydrolysis to 5.2-5.9 (243). A value of 7.8 has been quoted as optimum for activity of gastric lipases of dog, rabbit, and man (16), but it has been shown more recently that... 

S. Iverson, C. Kirk, M. Hamosh, and J. Newsome. Milk lipid digestion in the neonatal dog the combined actions of gastric and bile salt stimulated lipases. Bhcflim, Blopkys. Ada J083 109 (1991). 

R. (1993 b) Gastric and pancreatic lipase levels during a test meal in dogs, Scand. J. Gastroenterol. 28, 443-454. 

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