DNA Binders

DNA Binders and Related Subjects Volume Editors Waring, M.J., Cbaires, J.B. Vol. 253,2005... 

Attempts have been made to prepare carborane-containing DNA binders by adding carborane units to representative DNA intercalators (acridine, ethidium) and a DNA groove binder (distamysine), which have high binding affinity with DNA (Scheme 2.2-8). The intercalators insert themselves into a gap between the base pairs of double-helical DNA [32, 33]. 

The ability of DNA-binding drugs to induce chromatin condensation calls for in-depth studies, because the biological consequence of chromatin condensation is its loss of transcriptional ability. Therefore it might be a mechanism of transcription inhibition by the reversible DNA binders. The first report in this line (Sen and Crothers, 1986) employed transient electric dichroism to study the ability of the drugs to induce folding of chromatin from the 10- to 30-nm fiber either by... 

Broggini M, Marchini S, Fontana E, Moneta D, Fowst C, Geroni C. (2004) Brostallicin A new concept in minor groove DNA binder development. Anti-Cancer Drugs 15 1-6. 

SRY (DNA binder) Pepsyn KA flow Fmoc, tBu TBTU, HOBt 1992 [62]... 

In 1993, the effects of selected topoisomerase II inhibitors, antimalarial agents, DNA binders, naphthoquinones, and various other agents on integrase activity in vitro were investigated [46]. 

Anderson RF, Fisher LJ, Elara Y, Harris T, Mak WB, Melton LD, Packer JE (2001) Green tea catechins partially protect DNA from OEI radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. Carcinogenesis 22 1189-1193 Anderson RF, ElarrisTA, Elay MP, Denny WA (2003a) Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine. Chem Res Toxicol 16 1477-1483... 

The mechanism of aptamer action (competitive or non-competitive) is predicted by the choice of the agonist or antagonist for the displacement of high-affinity RNA or DNA binders to a receptor during the SELEX process. 

Keywords DNA binder Double-helical structure Intercalation Molecule device Nanostructure... 

Takashima H,Tara C, Namikawa S, Kato T, Araki Y, Ito O, Tsukahara K. Photoinduced intramolecular electron-transfer reactions of reconstituted met- and zinc-myoglobins appending acridine and methylacridinium ion as DNA-binders. J Phys Chem B 2006 110 26413-23. 

Ito, K., Hashimoto, K., and Ishimori, Y., 1996. Quantitative analysis for solid-phase hybridization reaction and binding reaction of DNA binder to hybrids using a quartz crystal microbalance. Anal. Chim. Acta, 3TI, pp. 29-35. 

The ideal cytotoxic dmg is a small molecule that is stiU very potent. A promising class of cytotoxic agents is a group of radiomimetic substances called ene-diyenes these are secondary metaboHtes from Streptomyces that are minor groove DNA-binders and introduce double-strand breaks that may lead to apoptosis [112-114] (Fig. 1.8). Their anti-tumor potential has been investigated in a number of experimental studies [115-117]. 

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