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DMBA-TPA

Skin 11 Inhibition of DMBA/TPA induced skin tumors (Oral application) [43]... [Pg.46]

Assay for Iinhibition of DMBA/TPA Induced Skin Tumors in Mice... [Pg.48]

Fig. (5) A shows the time dependence of skin tumor formation in the groups treated with DMBA plus TPA with or without 2.0 pM each of taraxasterol (239) and faradiol (232). The first tumor appeared at week 11 in the group treated with DMBA/TPA. In the groups treated with DMBA/TPA and 239, the first tumor appeared at week 13. Of mice treated with DMBA/TPA, 73% were tumor-bearing at week 20, as compared 20% in the group treated with DMBA/TPA and 239. Fig. (5) B shows the average number of tumors per mouse. The group treated with DMBA/TPA produced 7.1 tumors per mouse at week 20, whereas the group treated with DMBA plus TPA and 239 had 1.0 tumor per mouse. The treatment with 232 caused an 80% reduction in the average number of tumors per mouse at week 20. In the group treated with DMBA/TPA and 232, no tumors had appeared at week 20 [85]. Fig. (5) A shows the time dependence of skin tumor formation in the groups treated with DMBA plus TPA with or without 2.0 pM each of taraxasterol (239) and faradiol (232). The first tumor appeared at week 11 in the group treated with DMBA/TPA. In the groups treated with DMBA/TPA and 239, the first tumor appeared at week 13. Of mice treated with DMBA/TPA, 73% were tumor-bearing at week 20, as compared 20% in the group treated with DMBA/TPA and 239. Fig. (5) B shows the average number of tumors per mouse. The group treated with DMBA/TPA produced 7.1 tumors per mouse at week 20, whereas the group treated with DMBA plus TPA and 239 had 1.0 tumor per mouse. The treatment with 232 caused an 80% reduction in the average number of tumors per mouse at week 20. In the group treated with DMBA/TPA and 232, no tumors had appeared at week 20 [85].
Fig. (6) A shows the time dependence of skin tumor formation in the group treated with DMBA/TPA, with or without 0.2 pM each of 232 and heliantriol C (236). The first tumor appeared at week 8 in the group treated with DMBA/TPA. In the group treated with DMBA/TPA and 232 and 236, the first tumor appeared at weeks 10 and 13, respectively. The percentage of tumor-bearing mice treated with DMBA/TPA was 93% at week 20,... Fig. (6) A shows the time dependence of skin tumor formation in the group treated with DMBA/TPA, with or without 0.2 pM each of 232 and heliantriol C (236). The first tumor appeared at week 8 in the group treated with DMBA/TPA. In the group treated with DMBA/TPA and 232 and 236, the first tumor appeared at weeks 10 and 13, respectively. The percentage of tumor-bearing mice treated with DMBA/TPA was 93% at week 20,...
Soyasapogenol B, soyasaponins I and II and wistariasaponins from Wistaria brachybotrys (wistariasaponin C corresponds to astragaloside VIII) decreased (20-30%) the Epstein-Barr Virus (EBV) activation induced by the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) in Raji cells at a concentration of lxlO2 mol ratio [151]. Soyasaponin I from the same plant exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two-stage DMBA-TPA carcinogenesis test in vivo. Soyasaponin I reduced the number of papillomas per mouse at about 40% even at 20 weeks [152]. [Pg.222]

Inhibition of A -nitrobis-(2-hydroxypropyl)amine (BHP) induced pancreatic tumors Inhibition of DMBA/TPA induced skin tumors Inhibition of DMBA/teleocidin B induced skin tumors Inhibition of DMBA/fumonsin-Bl induced skin tumors Inhibition ofNOR-l/TPA induced skin tumors Inhibition of DMBA/okadaic acid induced skin tumors Inhibition of DMBA/mineral oil induced skin tumors... [Pg.76]

Balmain and coworkers (22) have recently found that a percentage of papillomas and carcinomas induced by DMBA-TPA contained elevated levels of Ha-ras transcripts compared with normal epidermis. Furthermore, the tumor... [Pg.87]

Many compounds that inhibit EBV-EA induction by TPA have been shown to act as inhibitors of tumor promotion in vivo [28]. Soyasaponin I (26) exhibited remarkable inhibitory effects on mouse skin tumor promotion on the basis of the two stage (DMBA-TPA) carcinogenesis... [Pg.642]

As already shown, tubeimoside 1 (5) from Bobolstemma paniculatum exhibited a strong anti-tumor activity, but had intriguingly a potent antitumor-promoting effect in two-stage mouse skin tumor formation induced by DMBA+TPA [38]. Its natural analog, tubeimoside III showed also a potent anti-tumor-promoting effect in the same model after topical administration but not after oral administration [39]. [Pg.645]

See other pages where DMBA-TPA is mentioned: [Pg.63]    [Pg.64]    [Pg.171]    [Pg.78]    [Pg.78]    [Pg.120]    [Pg.188]    [Pg.111]    [Pg.114]    [Pg.115]    [Pg.643]    [Pg.182]    [Pg.244]    [Pg.290]    [Pg.473]    [Pg.201]    [Pg.338]    [Pg.122]    [Pg.242]   
See also in sourсe #XX -- [ Pg.21 , Pg.642 , Pg.643 , Pg.645 ]

See also in sourсe #XX -- [ Pg.642 , Pg.643 , Pg.645 ]



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DMBA

DMBA/TPA induced skin tumor

Induced skin tumor by DMBA/TPA

TPA

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