Divinyl ether-maleic anhydride copolymer

Material. Methotrexate-y-hydrazide was prepared by a modified procedure described by Rosowsky (14). Divinyl ether-maleic anhydride copolymer was purchased from Hercules Incorporated (Wilmington, DE) and had an average molecular weight of 11,400. Centriprep-10 concentrators were purchased from Amicon (Danvers, MA). 

Polymeric N-oxides, like 2, show no activity in this test. An activation of the RHS-system has also been supposed to be die reason for the antitumor action of divinyl ether/maleic anhydride copolymers [5] which have been described for the first time by Regelson (32) as interferon inductors. 

Figure 1. The 90-MHz NMR spectrum of hydrolyzed divinyl ether-maleic anhydride copolymer in D,O at 58°C taken on a Nicolet NT-360WB.

FREEMAN AND BRESLOW Divinyl Ether-Maleic Anhydride Copolymer 249... 

Finally, our studies show all divinyl ether-maleic anhydride copolymers examined to date to be a mixture of the 5-membered and 6-membered bicyclic structures. The primary evidence for this, of course, is the presence of peak B at ca. 35 ppm which is assigned to the methylene carbon on a tetrahydropyran ring. Major features of the spectrum can be readily explained based on the available data present by both us and Professor Kunitake. However, still in question is the meaning of the fine structure contained particularly in peaks D, E, and F with respect to the relative stereochemistry of the copolymer as produced. 

VOL Volkova, I.F., Gorshkova, M.Yu., Izumrudov, V.A., and Stotskaya, L.L., Interaction of a polycation with divinyl ether-maleic anhydride copolymer in aqueous solutions (Russ.), Vysokomol. Soedin., Ser. A, 46, 1388, 2004. 

The interaction of polymer-solvent affects rheological properties. Studies on a divinyl ether-maleic anhydride copolymer show that molecular structure of die copolymer can be altered by the solvent selected for synfliesis." Studies have shown that the thermal and UV stability of PVC is affected by the presence of solvents. ... 

Abstract. Pyran Copolymer (Divema, NSC46015 ), a synthetic polyanion, divinyl ether maleic anhydride copolymer, has achieved clinical trial because of antitumor activity and its role as an anti-viral agent. Most of the previous biologic and clinical work with this agent has been done with pyran copolymer of an average molecular weight of 18000. (NSC46015). 

In addition to divinyl ether maleic anhydride copolymers, such as NSC 46015 (pyran copolymer, Divema) and E/MA synthetic polyanions, a number of poly-carboxylic antitumor polyanions have been synthesized by others (Guile, 1962 Butler, 1964 Hodnett, 1969 Ottenbrite, 1974). 

The Drug Development Branch of the National Cancer Institute and our own laboratories demonstrated antitumor activity for divinyl ether maleic anhydride copolymers. Samples of polycarboxylic divinyl ether maleic anhydride copolymer hydrolysate (NSC 46015 pyran 3,4-dicarboxylic anhydride, tetrahydro-2-methyl-6-(tetrahydro-2,5-dioxo-3-furyl) of average MW 17000 to 36000 show a broad spectrum of antitumor activity against transplanted tumors and a good therapeutic index. 

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