Disturbance of attention

The deficit of cortico-striatal innervation that is presumably responsible for reported losses of striatal glutamate uptake sites (Aparicio-Legarza et al., 1997 Simpson et al., 1992), is likely to contribute to the cognitive dysfunction of schizophrenia. These have been described as having similarities to the subcortical dementia (Pantelis et al., 1992) seen in a variety of neurodegenerative disorders disturbances of corticostriatal function are thought to underlie this pattern of cognitive deficits that include disturbances of attention, executive function and short-term memory. 

Systematic reviews A meta-analysis of clinical studies of the safety and efficacy of retigabine reported adverse effect rates of 46-73%, 60-80%, and 72-91.5% with retigabine doses of 600, 900, and 1200 mg/day, respectively [ISl j. The most common adverse effects included dizziness, somnolence, confusion, fatigue, headache, and speech disorder. Less common adverse effects were vertigo, dysarthria, blurred vision, diplopia, urinary tract infection, ataxia, tremor, amnesia, memory impairment, nausea, disturbance of attention, gait disturbance, and anxiety [151,152 ]. Adverse event rates were dose dependent and occurred mostly during the early titration phase [153 j. 

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