Disease dangers

Myasthenia gravis Epilepsy Cardiac arrhythmia Liver disease Kidney disease Danger of respiratory paralysis May provoke seiznres Exacerbated by local anaesthetics Rednced metabolism increases risk of side effects Rednced excretion increases risk of side effects... 

Year Inland/inshore . , . .. Over 3 Fatal Major Disease Dangerous occurrences Offshore Fatal Major Over 3 Days Disease Dangerous occurrences... 

Cytokines, eg, interferons, interleukins, tumor necrosis factor (TNF), and certain growth factors, could have antitumor activity directiy, or may modulate cellular mechanisms of antitumor activity (2). Cytokines may be used to influence the proliferation and differentiation of T-ceUs, B-ceUs, macrophage—monocyte, myeloid, or other hematopoietic cells. Alternatively, the induction of interferon release may represent an important approach for synthetic—medicinal chemistry, to search for effective antiinflammatory and antifibrotic agents. Inducers of interferon release may also be useful for lepromatous leprosy and chronic granulomatous disease. The potential cytokine and cytokine-related therapeutic approaches to treatment of disease are summarized in Table 4. A combination of cytokines is a feasible modaUty for treatment of immunologically related diseases however, there are dangers inherent in such an approach, as shown by the induction of lethal disserninated intravascular coagulation in mice adrninistered TNF-a and IFN-y. 

Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) ai e toxic compounds of anthropogenous origin, able to accumulate in tissues of alive organisms and to cause different diseases. These compounds ai e the most dangerous for aquatic ecosystems as they easily adsorb in sludge and ai e included in food chains of biota. Humans consume PCBs and OCPs mostly with fish. 

REPORTABLE DISEASE (uk) A dlscasc whlch luust be reported to the authorities when linked to specified types of work. (The Reporting of Injuries Diseases and Dangerous Occunences Regulations 1995.)... 

Reporting an Injury or a Dangerous OccuiTcnce. (RIDDOR) The Reporting of Injuries, Disease and Dangerous OccuiTcnces Regulations 1985... 

RIDDOR explained - Reporting of Injunes, Diseases and Dangerous Occurences Regulations RIDDOR 95 - Offshore... 

Reporting of Injuries, Diseases and Dangerous Occurrences Regulations (RIDDOR) 1995... 

Requirements for the reporting of certain categories of injury and disease sustained at work, and specific dangerous occuiTcnces or gas incidents, to the enforcing authority. 

Sewage becomes offensive due to its own instability together with the objectionable concentration of suspended materials. In addition, the potential presence of disease producing organisms makes sewage dangerous. Removal or stabilization of sewage matters may be accomplished in treatment works by a number of different methods or by a suitable combination of these methods. 

X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the gene for the vasopressin V2 receptor leading to an insensitivity of the kidney for the antidiuretic hormone arginine vasopressin (AVP). The main symptom of the disease is diuresis, i.e., the production of a large amount of diluted urine. Due to the massive loss of water, the patients suffer from thirst and are in danger of dehydration. The disease usually becomes evident shortly after birth. 

It is important to use these drag with caution in patients with a history of gastrointestinal disorders, renal disease, or liver impairment. The neuromuscular blocking action of die lincosamides poses a danger to patients widi myasthenia gravis (an autoimmune disease manifested by extreme weakness and exhaustion of die muscles). 

Ybu must report certain types of accidents and ill health at work, using Form 2508 or Form 2508A - see the Reporting of Injuries. Diseases and Dangerous Occurrences Regulations fRIDDORl 1995. 

RIDDOR explained. Reporting of Injuries, Diseases and Dangerous Occurrences Regulations 1995 HSE 31(rev1) HSE Books 1999 Also available in priced packs ISBN 0 7176 2441 2... 

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