Abuse liability discriminative stimulus effects

Negus SS Woods JH (1995). Reinforcing effects, discriminative stimulus effects, and physical dependence liability of buprenorphine. In Cowan A Lewis JW (eds.) Buprenorphine Combatting Drug Abuse with a Unique Opioid. New York Wiley-Liss, pp. 71-101... 

Holtzman, S.G., Discriminative stimulus effects of drug relationship to abuse liability, in Testing and Evaluation of Drugs of Abuse, M.W. Adler and A. Cowan, Eds., Wiley-Liss, New York, 1990. 

The principal weakness of drug discrimination procedures for assessing abuse liability is that they provide only indirect evidence regarding abuse. If a test substance is discriminated as being similar to a known drug of abuse, this is taken to indicate that the test substance is likely to be abused in a similar manner. On the other hand, if a test substance does not share discriminative stimulus effects with any known drug of abuse, drug discrimination procedures alone provide no indication of whether the test substance is likely to be abused. 

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