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Sunesis Pharmaceuticals

We thank all of our colleagues at Sunesis Pharmaceuticals for their contributions, without which Tethering would not have been possible, and Monya L. Baker for editorial assistance. Portions of this chapter appeared in a similar form in a previous book in this series [20], and Marcus D. Ballinger and James A. Wells both contributed to the editing of these sections. [Pg.318]

Tethering is a registered service mark of Sunesis Pharmaceuticals, Inc., for its fragment-based drug discovery. [Pg.319]

Researchers at Sunesis pharmaceuticals have developed a fragment-based drug discovery method termed tethering [25]. The approach, which is illustrated in Scheme 2.6, shares a number of features with DCC. Whereas protein-directed DCLs equilibrate small molecules via disulfide formation, say, in the presence of a protein that acts as a thermodynamic trap, tethering uses a cysteine residue on the protein surface to reversibly capture small-molecule thiol fragments from solution. Tethering is designed... [Pg.62]

Daniel A. Erlanson Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA... [Pg.292]

AIDS Community Research Cnsrt) Sunesis Pharmaceuticals Inc. [Pg.260]

A recent report from Sunesis Pharmaceuticals simultaneously uses multiple disulfide bonds to demonstrate a... [Pg.3434]


See other pages where Sunesis Pharmaceuticals is mentioned: [Pg.424]    [Pg.307]    [Pg.462]    [Pg.462]    [Pg.1091]    [Pg.10]    [Pg.3046]    [Pg.424]    [Pg.307]    [Pg.462]    [Pg.462]    [Pg.1091]    [Pg.10]    [Pg.3046]    [Pg.194]    [Pg.194]   
See also in sourсe #XX -- [ Pg.183 , Pg.251 ]




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