Dipyridamole clinical trials

Anon. Clinical trials on AIDS start. Reprowatch 1999 1—28 6—11. Garcia-Fuentes, E., A. Gil-Villarino, M. F. Zafra, and E. Garcia-Peregrin. Changes in plasma lipid composition induced by coconut oil. Effects of dipyridamole. J Physiol Biochem 2002 58(1) 33-41. 

A frequently cited mechanism of action for these agents is phosphodiesterase (PDE) inhibition and the associated antiplatelet effects that accompany increases in intracellular cyclic adenosine monophosphate (cAMP). In fact, the effects of these drugs go far beyond their direct effect on PDE inhibition or platelet function. This chapter discusses (/) cyclic nucleotides, PDE, and PDE inhibitors (if) the mechanisms of action of dipyridamole and cilostazol (Hi) drug issues and (iv) current clinical applications for dipyridamole and cilostazol, including recent clinical trials that may have changed our perception of the possible utility of these agents for percutaneous intervention. 

Clinical trials with dipyridamole for the reduction of thromboembolic complications after prosthetic cardiac valye replacement continue to show encouraging results.47 in a controlled study of 163 patients, dipyridamole (400 mg dally) significantly reduced the frequency of arterial emboli.56 On the other hand, dipyridamole was found to have no significant effect on postoperative deep vein thrombosis... 

A number of rather limited trials have been reported with agents such as aspirin, dipyridamole, sulfinpyrazone and cyproheptadine in a variety of clinical conditions. An example is a rather dramatic effect seen with aspirin and dipyridamole in a case of thrombotic thrombocytopenic purpura.39 variable results with these agents have also been previously reported in transient cerebral ischemia,40,41 platelet consumption following prosthetic heart valve surgery,42,43 and postsurgical venous thrombosis.44 Certainly results from clinical studies of a larger scale, such as those currently underway in the United States and Canada, will have to be completed before a valid assessment of the potential clinical utility of these agents can be made.45,46... 

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