Diphenyl- bromide

Rearrangement across the double bond and possible anchimeric assistance involving carbon also has been investigated. Rappoport and Gal (134) have reported that the solvolysis of l-anisyl-2,2-diphenyl bromide, 224, in aqueous ethanol as well as in formic acid gave a,a-diphenyl-p-methoxyacetophenone, 225, as the only product i.e., no rearrangement product 226 was observed. 

A number of indium trialkyls have been prepared, starting from the trimeihyl, and some diaryl compounds are known, such as the diphenyl bromide. The lower trialkyls are tetramers. Like aluminum, indium forms a polymeric hydride. (lnHil , from which lelrahydroindates. such as the lithium compound, LilnHj. can be derived. 

Diphenyl- -benzylamid E2, 233 Diphenyl- -bromid El, 210 Diphenyl- -tert.-butylester E2, 211 Diphenyl- -(5-tert.-butyl-2-hydroxy-3-methyI-anilid) E2, 236... 

SEE BRODIFACOUM. First reaction is with diphenyl of p-diphenyl bromide )... 

Thallium diphenyl bromide was first mentioned by Meyer and Bertheim in 1994, but in 1922 the present authors showed that this compound was impure, and that the reactions given for it did not represent the facts, as shown by them later preparation. They therefore claimed their preparation to be the first organometallic compound of thallium, in the aromatic series, to be obtained in the pure state. The compound, which is typical of the aromatic thallium diaryl halides, does not melt below 300 C., and may be crystallised from pyridine. The corresjjond-ing chloride is decomposed "by iodine monochloride according to the equation ... 

Boron diphenyl bromide was first obtained as a by-product in the preparation of boron phenyl dibromide, from boron tribromide and mercury diphenyL the compound being contained in the fraction distilling above 150° C. at 20 mm. It may be more readily isolated by taking the proportions represented by the following equation —... 

Thallium diphenyl bromide. —10-3 grams of thallic chloride in... 

Thallium diphenyl nitrite is obtained by boiling together thallium diphenyl bromide and silver nitrite in xylene solution for two and a half hours. The nitrite is deposited from pyridine in short, trans-parent needles, completely soluble in hot pyridine, slightly soluble in... 

CA Index Name 2//-Tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1 1)... 

Other Names 2//-Tetrazolium, 2-(4,5-dimethyl-2-thia-zolyl)-3,5-diphenyl, bromide 3-(4,5-Dimethyl-2-thiazo-lyl)-2,5-diphenyl-2//-tetrazolium bromide 2,5-Diphenyl-3-(4,5-dimethylthiazol-2-yl)-2H-tetrazolium bromide 2,5 -Diphenyl- 3- (4,5 -dimethylthiazol-2-yl)tetrazolium bromide 2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide 3-(4, 5 -Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide 3-(4,5-Dimethyl-2-thiazo-lyl)-2,5-diphenyltetrazolium bromide 3-(4,5-Di-methylthiazolyl)-2,5-diphenyl-2//-tetrazolium bromide 3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide MMT Tetrazolium MTT MTT Tetrazolium ... 

The reaction of cinnoline 2-oxide with phenylmagnesium bromide gives phenanthrene, trans- and cfs-stilbene, 2,3-diphenyl-l,2-dihydrocinnoline and 2-styrylazobenzene in yields of 1-15%. Analogous results are also obtained from 4-methylcinnoline 2-oxide. 

Reaction of pyridazine 1-oxide with phenylmagnesium bromide gives 1,4-diphenyl-butadiene as the main product and l-phenylbut-l-en-3-yne and 3,6-diphenylpyridazine as by-products, while alkyl Grignard reagents lead to the corresponding 1,3-dienes exclusively (79JCS(P1)2136>. 

Aryl-2-phenyl-4,5-dihydropyridazin-3(2//)-ones react either with phenylmagnesium bromide or with phenyllithium to give 6-aryl-2,6-diphenyl-l,4,5,6-tetrahydropyridazin-3(2//)-ones (135) (products of 1,2-addition to the azomethine bond), while 2-methyl-6-phenyl-4,5-dihydropyridazine-3(2//)-one reacts with two equivalents of phenylmagnesium bromide at the carbonyl and azomethine group to produce 2-methyl-3,3,6,6-tetraphenyl-hexahydropyridazine (136) (Scheme 53) (80JPR617). 

Thiazolyl blue tetrazolium bromide (MTT, 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2//-tetrazolium bromide) [298-93-1, 2348-71-2] M 414.3, m 171°. It is recrystd by dissolving in MeOH containing a few drops of HBr and then adding dry Et20 to complete the crystn, wash the needles with Et20 and dry in a vacuum desiccator over KOH. [Beyer and Pyl Chem Ber 87 1505 7954.]... 

Enby 6 is an example of a stereospecific elimination reaction of an alkyl halide in which the transition state requires die proton and bromide ion that are lost to be in an anti orientation with respect to each odier. The diastereomeric threo- and e/ytAra-l-bromo-1,2-diphenyl-propanes undergo )3-elimination to produce stereoisomeric products. Enby 7 is an example of a pyrolytic elimination requiring a syn orientation of die proton that is removed and the nitrogen atom of the amine oxide group. The elimination proceeds through a cyclic transition state in which the proton is transferred to die oxygen of die amine oxide group. 

I he aciioii also t.tkes pLtce between. iroin.atic htdiocitibons sLibstittUed either in the mu lens 01 side-chain. liromoben/.cne yields diphenyl, where.ts beii/yl bromide yields diben/.yl,... 

The formation of diphenyl on oxidation of phenyl magnesium bromide by anhydrous ferric chloride has been known for some... 

Methyl-2-phenyl-5-oxazolone (22) reacts with excess phenyl-magnesiuin bromide to give 2-benzainido-1,1-diphenyl-1-propanoP (23). With excess ethylmagnesium bromide, 22 forms a dimer, N,N -... 

Chloro-5,6-diphenyl-as-triazine readily undergoes methoxy-de-chlorination at 25° (< 12 hr) with methanolic methoxide and at 65° (4.5 hr) in non-basified methanol. The chloro group is also displaced by hydrazine (80°, 1 hr), ammonia (140°, 6 hr), and phenyl-magnesium bromide (70°, 12 hr), the latter forming the triphenyl compound 315.3-Chloro-6-phenyl-as-triazine is unstable to cold water or alkali and to hot alcohol or aqueous potassium carbonate. ... 

Bromination of the diphenyl indole derivative 316 with bromine in DMF or trimethylammonium bromide afforded the 7-bromo derivative 317. Reaction with allyl bromide or its derivatives gave A-allyl derivatives 318 that upon cyclization with palladium acetate gave 7,9-dimethoxy-l,2-diphenylpyrrolo[3,2,l-// ]quinoline derivatives 319 (92T7601) (Scheme 57). 

Esters of diphenylacetic acids with derivatives of ethanol-amine show mainly the antispasmodic component of the atropine complex of biologic activities. As such they find use in treatment of the resolution of various spastic conditions such as, for example, gastrointestinal spasms. The prototype in this series, adiphenine (47), is obtained by treatment of diphenyl acetyl chloride with diethylaminoethanol. A somewhat more complex basic side chain is accessible by an interesting rearrangement. Reductive amination of furfural (42) results in reduction of the heterocyclic ring as well and formation of the aminomethyltetrahydro-furan (43). Treatment of this ether with hydrogen bromide in acetic acid leads to the hydroxypiperidine (45), possibly by the intermediacy of a carbonium ion such as 44. Acylation of the alcohol with diphenylacetyl chloride gives piperidolate (46). ... 

Diphenylacetonitrile is condensed with 2dimethyl-amino)-2,2-diphenyl valeronitrile. It is then reacted with ethyl magnesium bromide and then hydrolyzed using HCl to give methadone hydrochloride. 

Preparation of 1,3-Diphenyl-2,2-Dimethylpropanone-1 Sodamide was prepared from 12.5 grams of sodium added in small portions to 600 cc of liquid ammonia with 1 gram of hydrous ferric chloride as catalyst. The ammonia was replaced by 200 cc of dry toluene and without delay a solution of 74 grams of isobutyrophenone and 76.5 grams of benzyl bromide in 200 cc of benzene was slowly added with stirring. The reaction mixture was heated on a boiling water bath for 48 hours. Water was then added, the organic layer separated and the product isolated by distillation. The 1,3-diphenyl-2,2-dimethylpropanone-1 boiled from 142°-143°C at a pressure of 3 mm, t ° 1.5652. 

A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4-piperidino4-pi-peridinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and re-crystalli2ed from 320 parts of acetone, to give 1 -(3,3-diphenyl-3-cyanopropyl)4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C. 

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