Dioxygenase activity

During, A., Albaugh, G., and Smith, J.C., Characterization of 3-carotene 15,15-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2 cells, Biochem. Biophys. Res. Commun., 249, 467, 1998. 

During, A. et al., P-Carotene 15,15-Dioxygenase activity in human tissues and cells evidence of an iron dependency, J. Nutr. Biochem., 12, 640, 2001. 

During, A. et al., Assay of P-carotene 15,15-dioxygenase activity by reverse phase high-pressure liquid chromatography, Anal. Biochem., 241, 199, 1996. 

Hintner J-P, C Lechner, U Riegert, AE Kuhm, T Storm, T Reemtsma, A Stolz (2001) Direct ring fission of salicylate by a salicylate 1,2-dioxygenase activity from Pseudaminobacter salicyloxidans. J Bacterial 183 6936-6942. 

The transformation of carbazole has been examined, and naphthalene 1,2-dioxygenase activity was induced in Pseudomonas sp. strain NCIB 9816-4 and in Beijerinckia sp. strain B8/36 (Resnick et al. 1993). The 3-hydroxycarbazole that was formed could have resulted from two pathways (a) from the initial production of ciy-3,4-dihydro-3,4-dihydroxycarbazole followed by dehydration or (b) by monooxygenation that cannot be excluded since monooxygenase activity can be mediated by naphthalene 1,2-dioxygenase (Gibson et al. 1995). 

Haroune N, B Combourieu, P Besse, M Sancelme, T Reemtsma, A Kloepfer, A Diab, JS Knapp, S Baumberg, A-M Delort (2002) Benzothiazole degradation by Rhodococcus pyridinovorans strain PA evidence of a catechol 1,2-dioxygenase activity. Appl Environ Microbiol 68 6114-6120. 

Ralstonia eutropha (Alcaligenes eutrophus) strain NH9 is able to degrade 3-chlorobenzene by the modified ortho pathway. The cbnA gene that encodes 3-chlorocatechol-l, 2-dioxygenase was introduced into rice plants (Oryza sativa -p.japonicd) under the control of a virus 35S promoter. 3-Chlorocatechol induced dioxygenase activity in the callus of the plants, and leaf tissues oxidized 3-chlorocatechol with the production of 2-chloromuconate... 

Sassanella TM, F Fukumori, M Bagdasarian, RP Hausinger (1997) Use of 4-nitrophenoxyacetic acid for detection and quantification of 2,4-dichlorophenoxyacetic acid 2,4-D/a-ketoglutarate dioxygenase activity in 2,4- D-degrading microorganisms. Appl Environ Microbiol 63 1189-1191. 

One of the most important applications of PPO, although rarely reported, is its role in synthetic processes, such as the biosynthesis of betalains. Several researchers reported the hydroxylation of tyrosine to dopa, which can then be oxidized to dopaquinone, through a PPO from Portulaca grandiflora and from Beta vulgaris. Thus, a dioxygenase activity complements the constitutive PPO activity and the initiation of this dioxygenase... 

Strain PI5 was grown on phenanthrene by a known pathway in which salicylate is an intermediate. Pre-incubation with phenanthrene and downstream intermediates through salicylate stimulated PAH dioxygenase activity and initial rates of phenanthrene removal, suggesting that salicylate was the inducer of this activity. 

With the exception of the binary system RhCl3/Cu(Cl04)2 [9,24], which incorporates the two atoms of dioxygen to the substrate (dioxygenase activity) (Eq. 1) all the rest show monooxygenase activity, incorporating only one oxygen atom to the substrate. 

Werner ER, Werner-Felmayer G, Fuchs D, Hausen A, Reibnegger G, Wachter H (1989) Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J 262 861-866... 

Benzoate 1,2-dioxygenase was shown to catalyze the conversion of benzoate to l,2-dihydro-l,2-dihydroxybenzoic acid (DHB) in the presence of NADH and oxygen by Reiner et al.205, 206). Yamaguchi et al.61> have demonstrated that the enzyme system consists of two components (A and B),both of which are required for benzoate 1,2-dioxygenase activity. Component A shows NADH-cytochrome c reductase activity and component B appears to be dioxygenase, thus the following reaction scheme is suggested [Eq. (25)]. 

Ensley, B. D., Osslund, T. D., Joyce, M. Simon, M.J. (1987). Expression and complementation of naphthalene dioxygenase activity in Escherichia coli. In Microbial Metabolism and the Carbon Cycle, ed. S. R. Hagedorn, R. S. Hanson D. A. Kunz, pp. 437-55. New York Harwood Academic Publishers. 

In contrast, NIST Standard Reference Material SRM 1939 from Hudson River sediment in New York state had an EF of 0.7 for PCB 95 (Equation (4.4) on Chirasil-Dex) [70]. Similar nonracemic residues were reported for PCBs 95,136,149,174, and 183 in this SRM [106]. These sediments are heavily contaminated with PCBs from historical releases from the General Electric capacitor plant in Schenectady, New York. Microbially mediated biotransformation of PCBs has occurred in these sediments by both anaerobic reductive dechlorination [155] and aerobic oxygenase and dioxygenase activity [153]. A subsequent. 

In isolated hepatocytes, after maximum induction of tryptophan dioxygenase by glucocorticoids, the uptake of tryptophan into the cells has a control coefficient of 0.75, whereas the control coefficient of tryptophan dioxygenase falls to 0.25. Therefore, the induction of tryptophan dioxygenase has only a limited effect on tryptophan catabolism and NAD synthesis (Salter and Pogson, 1985 Salter et al., 1986). In isolated perfused liver, although cortisol leads to a several-fold increase in tryptophan dioxygenase activity, there is only a relatively small increase in the rate of clearance of tryptophan from the perfusion medium (Kim and Miller, 1969). 

Grolier P, Duszka C, Borel P, Alexandre-Gouabau MC, and Azais-Braesco V (1997) In vitro and in vivo inhibition of heta-carotene dioxygenase activity by canthaxanthin in rat intestine. Archives of Biochemistry and Biophysics 348,233-8. 

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