Maleic anhydride, 1,3-dioxepin

Other polycarboxylates, such as Carbetimer, poly(maleic anhydride-co-cyclohexyl-l,6-dioxepin) and poly (maleic anhydride-co-4-methylpentenane), elicit a similar broad spectrum of activity. 

Free Radical Copolymerization of 4,7-Dihydro-1,3-dioxepins with Maleic Anhydride and Maleimides Preparation of Head-to-Head Poly(4-hydroxycrotonic acid) and Poly( -crotonolactone)... 

As part of an ongoing program to prepare and study new, water soluble polymers, attention was focused on the possible radical copolymerization of 4,7-dihydro-l,3-dioxepins with maleic anhydride (MA) and maleimides. 

A sample of poly (2,2-diraethyl-4,7-dihydro-l,3-dioxepin-alt-maleic anhydride) polymers was fractionated and briefly examined for antiviral properties (31). The copolymer was fractionated through Amicon filters into a 1,000-10,000 and 10,000-30,000 molecular weight cuts. Both molecular weight fractions were examined for effect against mice inoculated (ip) with 106 Ehrlich Ascites tumor cells. Five days after inoculation the animals were sacrificed and total peritoneal exudate cells were counted with a hemo-cytometer. Under these conditions, Ottenbrite (31) showed that the 1,000-10,000 molecular weight fraction of the ID-MA copolymer was as effective as Pyran (control in experiment) for control of Ehrlich Ascites tumor cells. Pyran, the copolymer of divinyl ether-MA is a well known antitumor agent (32) and interferon inducer (33). 

Uglea, C. V, Ottenbrite, R. M., Offenberg, H., Grecianu, A., and Negulescu, 1.1., Anesthesine modified maleic anhydride cyclohexyl-l,s-dioxepine copolymer. Preparation and potential medical application, 12th Annual Int. Conf. Eng. Med. Biol. Soc., Philadelphia, 1990. 

The action of a Zn/Cu couple on 1,3-dibromo ketones and secondary amides yields 2-dialkylamino-1,3-dioxolanes (451 equation 208). Fluorosulfonic peracid anhydride adds to trifluoroacetonitrile to give an amide acetal (452 equation 209). In the addition of (Z)-2-butene-l,4-diol to trichloroacetoni-trile, catalyzed by sodium, the 1,3-dioxepin (453 equation 210) is produced. Bicyclic amide acetals (454 equation 211) are byproducts in the reaction of lactim ethers with diketene. TTie methyl esters of perfluorinated carboxylic acids react with diethanolamine to afford bicyclic amide acetals (455 equation 212). Heating of maleic anilides (456 equation 213) with acetic acid anhydride/sodium acetate gives heterocyclic compounds (457) containing an amide acetal structure. ... 

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