Dimethyl phenazone

Determination of tungsten as the trioxide (tannic acid-phenazone method) Discussion. Tungstic acid is incompletely precipitated from solutions of tungstates by tannic acid. If, however, phenazone (2,3-dimethyl-l-phenyl-5-pyrazolone) is added to the cold solution after treatment with excess of tannic acid, precipitation is quantitative. This process effects a separation from aluminium, and also from iron, chromium, manganese, zinc, cobalt, and nickel if a double precipitation is used. 

Preparation 404.—Antipyrine, Phenazone (l-Phenyl-2 3-dimethyl-5-pyrazolone). 

SYNS DIMETHYLOXYQUINAZINE 2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE 2,3-DIMETHYL-l-PHENYL-5-PYRAZOLONE OXYDIMETHYL-QUINAZINE PHENAZONE (pharmaceutical) 1-PHENYL-2,3-DIMETHYL-PYRAZOLE-5-ONE 1-PHENYL-2,3-DIMETHYL-5-PYRAZOLONE... 

Antip-yfine 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one or Phenazone, listed in Beil as 1-Phenyl-2.3 -dimethyI-pyrazolon-(5) or... 

For the assay, 0.1 ml of homogenate is mixed with 0.3 ml of substrate solution in a small tube, and incubated at 38° for 20 minutes, taking 0.05-ml samples into 0.1 ml of 7% perchloric acid at 0, 6, 10, 15, and 20 minutes. After centrifugation, 0.05 ml of the supernatant is taken into a conical glass centrifuge tube, 0.05 ml of a 1% solution of dimethyl glyoxime in 96% ethanol added followed by 0.5 ml of an acid mixture made by dissolving 4 g of phenazone in a mixture of 76 ml of concentrated sulfuric acid, 11 ml of concentrated phosphoric acid and 163 ml... 

The parent compound (1) was discovered in 1891 by Tauber, who called it diphenyleneazone, and later phenazone. Unfortunately, the latter name was at one time also used for 2,3-dimethyl-l-phenylpyrazol-5-one (anti-pyrine). More recently 1 has been called 3,4-benzocinnoline and now benzo-[c]cinnoline, using Chemical Abstracts nomenclature. The numbering shown is that currently used Beilstein s Handbuch employed numbering analogous to that used for phenanthrene. 

Dihydro-3//-pyrazol-3-ones can be alkylated on the C-, N- or 0-atom depending on the substituents, reagent and reaction conditions. 5-Methyl-2-phenyl-2,4-dihydro-3//-pyrazol-3-one is methylated with iodomethane or dimethyl sulfate to give the 1,5-dimethyl derivative, which was one of the first synthetic drugs (1884, phenazone or antipyrine). It has antipyretic and antirheumatic action ... 

Dimethyl-1-phenyl-3-pyrazolin-5-one 1,2-Dihydro-l, 5-dimethyl-2-phenyl-3H-pyrazol-3-one Antipyrin Phenazone B.P., Eur. P, Int. P, Antipyrine U.S.P. 

It may be prepared by the eondensation of one mole each of phenyl-hydrazine and the lactim-form of ethylacetoacetate when 1-phenyl-3-methyl-pyrazolone is obtained by the elimination of a mole each of water and ethanol. The resulting product is subjected to methylation either with methyl iodide or dimethyl sulphate to yield phenazone. 

Dimethyl-1-phenyl-5-pyrazolone Oxydimethylquinazine Phenazone 1-Phenyl-... 

Phenazone is a pyrazoline derivative, chemically 2,3-dimethyl-l-phenyl 3-pyrazolin-5-one, available in white crystals or white crystalline powder soluble in water. Phenazone is well known for its analgesic and antipyretic actions. 

Methy1-10-athyI-phenazon.(3) 23, 415. l.S-Dimethyl.2-[2-oxy.phenyI]-benzijnid ... 

Synonyms 1,2-Dihydro-l,5-dimethyl-2-phenyl-3H-pyrazol-3-one phenazone... 

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