Phenazone

Phenylhydrazine condenses with acetoacetic ester to give a pyrazolone derivative which on methylation gives phenazone. The sulphonic acid similarly gives rise to the tartrazine dyestuffs. It is used to make indole derivatives by the Fischer process. 

Polysulfide Melt. Cl Sulfur Black 1 [1326-82-5] (Cl 53185), derived from 2,4-dinitrophenol, is the most important dye in this group which also includes the indophenol-type intermediates. The latter are appHed in the stable leuco form. The derived dyes are usually confined to violet, blue, and green shades. Other members of this group are intermediates capable of forming quinoneimine (10) or phenazone stmctures (11) that produce red-brown or Bordeaux shades ... 

With the exception of the phenazones, these compounds lead to formation of the thiazinone ring stmcture (12) which closely resembles the phenazone ring system. 

Metallic additions to the melt, usually in the form of copper sulfate, brighten the shade of certain dyes, such as the Bordeaux range made from phenazones and the greens made from the indophenols the metal forms a complex with the dye. However, copper-containing dyes cannot be appHed to material that requires vulcanization. 

Bromocresol green (3.8...5.4) aliphatic carboxylic acids[103,187 — 204] triiodobenzoic acid [205], derivatives of barbituric acid [206] amphetamine derivatives [207, 208] phenazones, morazone [209] alkaloids [91, 209] nephopam [210] phenyramidol metabolites [211] diethylalkylacetamide derivatives [212] zipeprol (Mirsol) [213] thalidomide and hydrolysis products [214] cyclohexylamine derivatives [215] herbicide residues [216]... 

Determination of titanium with tannic acid and phenazone Discussion. This method affords a separation from iron, aluminium, chromium, manganese, nickel, cobalt, and zinc, and is applicable in the presence of phosphates and silicates. Small quantities of titanium (2-50 mg) may be readily determined. 

Determination of tungsten as the trioxide (tannic acid-phenazone method) Discussion. Tungstic acid is incompletely precipitated from solutions of tungstates by tannic acid. If, however, phenazone (2,3-dimethyl-l-phenyl-5-pyrazolone) is added to the cold solution after treatment with excess of tannic acid, precipitation is quantitative. This process effects a separation from aluminium, and also from iron, chromium, manganese, zinc, cobalt, and nickel if a double precipitation is used. 

Notes. (1) The filtrate must be colourless. If it is yellow, insufficient phenazone has been added. 

The special wash liquid contains 1 mL concentrated sulphuric acid, 10 g ammonium sulphate, and 0.4 g phenazone in 200 mL of water. 

Titanium, D. of as oxide, via tannic acid and phenazone complexes, (g) 470 by hydrogen peroxide, (s) 696 Titan yellow 692 Titrand 257 Titrant 257 Titration 257 classification of, 258 in an inert atmosphere, 376, 629 in non-aqueous solvents, 281 aniline (and ethanolamine), D. of, 307 indicators for, 283 solvents for, 283... 

The second group of non-opioid analgesics, which are not classified as NSAIDs, consists of substances that lack anti-inflammatory properties, such as phenazones, metamizole (dipyrone) and paracetamol. Their molecules are neutral or weakly basic, have no hydrophilic... 

Pyrazolone derivatives are analgesic substances that have been known for a long time. The use of antipyrine (phenazone) and aminopyrine was sharply curtailed after their bone marrow toxicity was reported. Other derivatives, however, like phenylbutazone. 

Phenol concentration. When phenol is used to preserve a vaccine its concentration must not exceed 0.25% wA or, in the case of some vaccines, 0.5% w/v. Phenol is estimated by the colour reaction with amino-phenazone and hexacyanoferrate. 

Eichelbaum, M., Ochs, H. R., Roberts, G., Somogyi, A., Pharmacokinetics and metabolism of antipyrine (phenazone) after intravenous and oral administration, Drug Res. 1982, 32, 575-578. 

Phenacyl chloride, c31 Phenazone, a299 1,2,4-Phenenyl triacetate, tl 93 Phenethyl acetate, pill Phenethyl alcohol, pi 10 sec-Phenethyl alcohol, ml49 Phenethylamine, pi 12 Phenethyl bromide, b334 Phenethyl chloride, cl28 Phenetole, e36... 

Phenazone (182) was shown to be more photostable than amidopyrine or sulpyrine [116] however, several publications describe a number of photo-degradation products. After irradiation in methanol with a medium-pressure mercury lamp for 70 h, Ege isolated the carbamate (183,20%), the imidazolone... 

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