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Dimethyl formamide chemistry

In 2001, Sarko and coworkers disclosed the synthesis of an 800-membered solution-phase library of substituted prolines based on multicomponent chemistry (Scheme 6.187) [349]. The process involved microwave irradiation of an a-amino ester with 1.1 equivalents of an aldehyde in 1,2-dichloroethane or N,N-dimethyl-formamide at 180 °C for 2 min. After cooling, 0.8 equivalents of a maleimide dipo-larophile was added to the solution of the imine, and the mixture was subjected to microwave irradiation at 180 °C for a further 5 min. This produced the desired products in good yields and purities, as determined by HPLC, after scavenging excess aldehyde with polymer-supported sulfonylhydrazide resin. Analysis of each compound by LC-MS verified its purity and identity, thus indicating that a high quality library had been produced. [Pg.227]

Some recent developments in the research of the structure and dynamics of solvated ions are discussed. The solvate structure of lithium ion in dimethyl formamide and preliminary results on the structure of sodium chloride aqueous solutions under high pressures are presented to demonstrate the capabilities of the traditional X-ray diffiraction method at new conditions. Perspectives of solution chemistry studies by combined methods as e.g. diffraction results with reverse Monte Carlo simulations, are also shown. [Pg.229]

Polyvinylpyrrolidone (PVP) is a synthetic polymer derived from the Reppe chemistry and is widely used in the pharmaceutical, personal care, cosmetic, agriculture, beverage, and many industrial applications. PVP is a polar and amorphous polymer which is soluble in water and some organic solvents, such as alcohols, chlorinated hydrocarbons, dimethyl formamide, dimethyl acetamide, and V-methyl pyrrolidone. [Pg.1711]

The dimer is not readily soluble in water, although DHA is very soluble in water. Thus some questions have arisen as to the exact nature of BDHA in water. The dimer disassociates to a monomer in dimethyl formamide, dimethylacetamide, and pyridine (44) in agreement with earlier studies (45-47), A series of studies of AA and BDHA have now clarified many aspects of this problem. NMR studies of AA were published (48-51) that show the structure of AA in solution is essentially as proposed by classical carbohydrate chemistry and is the same as the structure found in crystalline ascorbic acid by x-ray crystallographic studies. Recent NMR studies of BDHA in dimethyl sulfoxide-de (DMSO-de) show that in this solvent BDHA is a mixture of two forms, a symmetric and an asymmetric dimer (52), The asymmetric form is thermodynamically favored. [Pg.107]

Radical nucleophile oxidation based on one-electron oxidation, known as the Minisci reaction, is employed for the functionalization of /V-heterocycles with acidic hydrogen peroxide in the presence of iron(II) salts (Figure 3.112).472 A range of A-heterocycles (pyridines, pyrazines, quinolines, etc.) which are activated towards attack by nucleophilic radicals when protonated are suited to this chemistry. The Minisci reaction is suitable for the preparation of carboxylic amides (from formamide), carboxylic esters (from pyruvic esters via a hydroxyhydroperoxide), aldehydes (from 1,3,5-trioxane) and alkylated pyridines (either from carboxylic acids or from alkyl iodides in dimethyl sulfoxide).473 The latter reaction uses dimethyl sulfoxide as the source of methyl radical (Figure 3.112). [Pg.163]


See other pages where Dimethyl formamide chemistry is mentioned: [Pg.229]    [Pg.799]    [Pg.39]    [Pg.343]    [Pg.799]    [Pg.101]    [Pg.487]    [Pg.887]    [Pg.146]    [Pg.340]    [Pg.137]    [Pg.7]    [Pg.838]    [Pg.134]    [Pg.487]    [Pg.225]    [Pg.91]    [Pg.109]    [Pg.303]    [Pg.68]    [Pg.669]    [Pg.613]    [Pg.111]   
See also in sourсe #XX -- [ Pg.241 , Pg.242 ]




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Dimethyl formamide

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Formamidate

Formamide

Formamide chemistry

Formamides

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