Dimethyl carbamoyl chloride

N,N-Dimethylaniline) Dimethylbenzene, see Xylene 1,3-Dimethylbutyl acetate Dimethyl carbamoyl chloride Dimethyl-1,2-dibromo-2,2-dichloroethyl phosphate, see Naled Dimethyl ether N-N-Dimethylethylamine Dimethylethoxy silane Dimethylformamide SK... 

Dimethylbutane, 56 Dimethyl carbamoyl chloride, 56 Dimethyldichlorosilane, 56 Dimethyldiethoxysilane, 56 Dimethyldisulfide, 56... 

The reaction of the enamines 28 and 113 with N,N-dimethyl carbamoyl chloride has been reported to give no isolable -keto amides 63). 

The enamino ketone (49) was reported to give no identifiable products on reaction with N,N-dimethyl carbamoyl chloride 63). However, reaction of (49) with N,N-diethyl carbamoyl chloride in refluxing chlorobenzene gave the N-(3-diethyl-amino-5,5-dimethylcyclohex-2-en-1 -ylidene)pyrrolidinium salt, isolated as the perchlorate. The latter must have been formed as outlined in Scheme I, involving initial O carbamoylation followed by an addition-elimination reaction to give 138 cation which can react with diethylamino anion by a further addition-elimination displacement to give the product 46). 

Starting from 2,4,6-octatriene and pivaldehyde, the conjugated homoallylic alcohol 8 is obtained as the sole product. Cycloheptatriene-derived complexes react with aldehydes and C02 to afford mixtures of the isomeric 1,3- and 1,4-cycloheptadienyl carbinols or acids, respectively. Interestingly, analogous reactions with methyl chloroformate or dimethyl carbamoyl chloride produce the conjugated dienyl ester 9 or amide 10 as unique products [19,20]. 

Toxicology. Dimethyl carbamoyl chloride is a skin, eye, and respiratory irritant it is carcinogenic in experimental animals by skin application and by subcutaneous or intraperi-toneal injection. 

One case of eye irritation and one of impaired liver function have been observed in workers exposed to dimethyl carbamoyl chloride. ... 

When rats were exposed to saturated vapors five of six or six of six died after 1 or 2 hours, respectively. Dimethyl carbamoyl chloride damaged the mucous membranes of the nose, throat, and lungs and caused difficulty in breathing, sometimes several days after exposure. Rats tolerated an 8-minute exposure to the saturated vapors and survived 14 days after exposure. Fifty-one of 100 rats exposed 6 hours/day for 15 days at lOppm succumbed. 

In long-term animal studies, dimethyl carbamoyl chloride produced local tumors by each of three routes of administration. Two milligrams applied to the skin of mice three times/week for 492 days caused skin papillomas in 40 of 50 animals of these, 30 progressed to skin carcinomas. After weekly subcutaneous injections of 5 mg for 26 weeks, 36 of 50 female... 

No cancer deaths or X ray indications of lung cancer were found in an investigation of 39 dimethyl carbamoyl chloride production workers, 26 processing workers, and 42 exworkers, aged 17-65, exposed for periods ranging from 6 months to 12 years. ... 

The lARC has determined that there is sufficient evidence in experimental animals for the carcinogenicity of dimethyl carbamoyl chloride and inadequate evidence in humans in its overall evaluation the lARC considers dimethyl carbamoyl chloride as probably carcinogenic to humans." ... 

Dimethyl carbamoyl chloride is a direct-acting alkylating agent with a wide spectrum of genotoxic activity." ACGIH has classified dimethyl carbamoyl as A2-a suspected human carcinogen with no threshold limit value (TLV). 

Oxazolo[4,5-/2]quinolin-2(3//)-ones could be acylated effectively at the N-3 position with reagents such as AcCl, ethyl chloroformate, trans-cinna.moy chloride, and dimethyl carbamoyl chloride... 

Dimethylbenzene. see Xylene 1,3-Dimethylbutyl acetate Dimethyl carbamoyl chloride... 

Dimethoxybenzindine Dimethyl aminoazobenzene 3,3 -Dimethyl benzidine Dimethyl carbamoyl chloride Dimethyl formamide... 

DIMETHYLCARBAMIC ACID CHLORIDE, DIMETHYLCARBAMIC CHLORIDE, DIMETHYLCARBAMIDOYL CHLORIDE, DIMETHYL CARBAMOYL CHLORIDE (79-44-7) or A,Af-DIMETHYLCARBAMOYL CHLORIDE (79-44-7) Combustible liquid (flash point 155°F/68°C). Rapidly hydrolyzed in water to dimethylamine, carbon dioxide, and hydrogen chloride. Violent reaction with strong oxidizers. Acid or acid fumes form toxic chloride fumes. Aqueous solution is incompatible with sulfuric acid, alkalis, ammonia, aliphatic amines, alkanolamines, alkylene oxides, amides, epichlorohydrin, organic anhydrides, isocyanates, vinyl acetate. May increase the explosive sensitivity of nitromethane. Attacks austenitic stainless steels, causing pitting and stress corrosion. 

The acylations with N,N-dimethylformamide, N,N-dimethylbenzamide, dimethyl-carbamoyl chloride and methyl chloroformate, discussed in this section are illustrated by experimental procedures. The derivatization reactions shown below, generally give the best results with lithium derivatives in THF or Et2Q and in most... 

Pyrolan . Dimethylcarlramu acid 3-methyl-I-pbinyl-1H-pyrazol-5-yl ester 1 -phen yl -3 -methyl -5-pyra-zolyl dimethyIcarbamate 3 -methyl. 1 -phenyl. 5 -pyrazolyI dimcthylcarbamate ENT 17588 G-22008. CuH.jNsOj mol wt 245.27. C 63.66%, H 6.16%, N 17.13%, O 13.05%. Prepn from 1-phenyl-3-methyl-5-pyrazolone and dimethyl -carbamoyl chloride Swiss pat. 279,353 (19S2 to Geigy) Brit. pat. 681,376. Anticholinesterase activity Pulver,... 

Dimethylcarbamic chloride [Dimethyl carbamoyl chloride] CjH ClNO 79-44-7 0.005 mg/m ... 

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