3,10-Dihydroxy-5,8-diacetoxy

Dihydroxy-5,8-diacetoxy-l(2), ll(12)-de-hydro farnesol C19H30O7 354 IR, hnmr, C NMR, APT, HETCOR, COLOC, E1MS,HRMS 93... 

Pancuronium bromide 16a 1 -Diacetoxy-11/3,17a-dihydroxy-9a-fluoro-4-pregnene-3,20-dione Triamcinolone diacetate la 5-Diacetoxyprecholecalciferol Calcitrlol... 

Dihydroxy-16a-carboxy- 157 3/3,21 -Dihydroxy-16a, 17a-epoxy- 779 3,20-Dioxo-16 -carboxy- 157 3/3-Hydroxy-16a-acetoxy-20-oxo- 514 17a-Hydroxy-3/ ,21-diacetoxy-20-oxo- 778 3/3-Hydroxy-16a, 17a -epoxy-20-oxo- 779... 

The original preparation of y-crotonolactone by Lespieau involved a five-step sequence from epichlorohydrin and sodium cyanide. A recent detailed study of this procedure reported an overall yield of 25% for the lactone. Glattfeld used a shorter route from glycerol chlorohydrin and sodium cyanide hydrolysis and distillation of the intermediate dihydroxy acid yielded y-cro-tonolactone in 23% yield and -hydroxy-y-butyrolactone in 28% yield. The formation of y-crotonolactone in 15% yield has also been reported from pyrolysis of 2,5-diacetoxy-2,5-dihydrofuran at 480-500 . ... 

Heptane, 2(R)-5(S)-dihydroxy-l 7-bis- (4-hy-droxy 3-methoxy-phenyl) Rh 0.00056% Heptane, 2-2-4-trimethyl Rh Heptane, 3(S)-5(S)-diacetoxy-l-(4 -hy-droxy-3 -5 -dimethoxy-phenyl) 7-(4"-hy-droxy-3 -methoxy-phenyl) Rh 20 ° Heptane, 3(S)-5(S)-diacetoxy-l-7-te-(3-4-dihydroxy-phenyl) Rh 15.7 ° ... 

Heptane, 3-5-diacetoxy-1 7-te-(4 hydroxy-3-methoxy-phenyl, MeSO Rh 40.8 °° Heptane, 3-5-diacetoxy 7 (3-4-dihydroxy-pheny 1) -1 - (4-hydroxy-3 -methoxy-pheny 1) Rh 3.5 ° ... 

The n.m.r. spectra of several 5,6-dihydroxyindoles (and their diacetyl derivatives) obtained by reduction of different non-halo-genated aminochromes were compared with those obtained from the appropriate 5,6-dihydroxy-(or 5,6-diacetoxy)-iodoindoles produced by reduction of the corresponding iodoaminochromes. The n.m.r. data clearly demonstrated the presence of a- and /3-protons in the indole nuclei (except in the case of the products derived from 2-methylnoradrenochrome and the corresponding iodoaminochrome,... 

C2sHioOb 96670-24-5) see Triamcinolone diaectate 5a,2l-diacetoxy-6p-fluoro-3p,17-dihydroxy-lfitx-methyl-pregnan-20-one... 

SYNS CERVICUNDIN 3-P,17- 3-DIACETOXY-17-a-ETHYNYL-4-OESTRENE 3-P,17- 3-DIACETOXY-19-NOR-17-a-PREGN-4-EN-20-YNE ETHINODIOL DIACETATE ETHYNODIOL DIACETATE P-ETHYNODIOL DIACETATE 17-a-ETHYNYL-3,17-DIHYDROXY-4-ESTRENE DIACETATE 17-a-ETHYNYLESTR-4-ENE-3-P,17-P-DIOL ACETATE 17-a-ETHYNYL-4-ESTRENE-3-P,17-DIOL DIACETATE 17-a-ETHYNYL-4-ESTRENE-3-P,17-P-DIOL DIACETATE 17-0-ETHYNYL-19-NORANDROST-4-ENE-3-P,17-P-DIOL DIACETATE FEMULExN LUTO-METRODIOL METRODIOL METRODIOL DIACETATE (3-P,17-a)-19-NORPREGN-4-EN-20-YNE-3,17-DIOL DIACETATE OVULEN 50... 

Hydrolysis of 2,6-diacetoxy-3,5-diphenylpyrazine (9) (from 2-hydroxy-3,5-diphenylpyrazine 1 -oxide by refluxing with acetic acid-acetic anhydride) with potassium hydrogen carbonate in methanol gave 2,6-dihydroxy-3,5-diphenylpyrazine (873), and 2-acetoxy-6-methoxycarbonylpyrazine (from 3-methoxycarbonyl-pyrazine 1-oxide with acetic anhydride) with methanolic hydrogen chloride gave 2-hydroxy-6 -methoxycarbonylpyrazine (838). 

When 2-hydroxy-3,5-diphenylpyrazine 1-oxide was heated under reflux with an excess of acetic anhydride, a crystalline triacetoxy compound was obtained which was thought to have an open chain structure [AcO-CH=CPh-N=CPh-C(OAc)=N-OAc], but when the 2-hydroxypyrazine-l-oxide was boiled with a mixture of acetic anhydride and acetic acid, 2,6-diacetoxy-3,5-diphenylpyrazine was obtained (873) which was hydrolyzed by potassium hydrogen carbonate in methanol to 2,6-dihydroxy-3,5-diphenylpyrazine (873). 2-Hydroxy-5-methyl-3-phenylpyrazine 1-oxide behaved differently and when refluxed with acetic anhydride gave 5-acetoxymethyl-2-hydroxy-3-phenylpyrazine (100) and 2-hydroxy-3-methyl-5-phenylpyrazine 1-oxide similarly gave 3-acetoxymethyl-2-hydroxy-5-phenylpyrazine (873). When 2- l-hydroxy-2 -methylpropyl)-5-isobutylpyrazine 1-oxide was heated with a mixture of acetic anhydride and sodium acetate on a water bath 2-(l -acetoxy-2 -methylpropyl)-5-isobutylpyrazine 1 oxide was obtained (760a). 

Besides sulphated PS, reports on anti-HSV compounds isolated from marine algae are recorded in the literature. Specimens of the brown alga Dictyota pfaffii from Atol das Rocas, northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2,6-dolabella-diene and the new 10-acetoxy-8,18-dihydroxy-2,6-dolabella-diene [46]. These substances showed strong anti-HSV-1 activity in vitro. Several antiviral diterpenes were isolated from other brown algae of the Dictyota genus. 

Ozone on silica gel introduces a 25-hydroxy-substituent into suitable compounds with a cholestane side-chain. By using the la,3/8-diacetoxy-6/8,7a-dibromo-derivative (383), prepared from the known 6-ene, the 25-hydroxylated compound was obtained as the only product (11% conversion). Trifluoroacetylation followed by dehydrobromination afforded the 5,7-diene (385), which was transformed into la,25-dihydroxy-vitamin D3 by the usual method. 

Diacetoxy-3-methoxyphenanthrene and triacetylisothebenine are obtained by the acetolysis of sinomenine hydrate and the 1-bromo-derivatives of these can be prepared in the same way from 1-bromosinomeninone. Catalytic reduction of both triacetylisothebenine and its 1-bromo-derivative affords triacetyl-9 10-dihydroisothebenine [55], believed by Schopf, Pfeiffer, and Hirsch [64] to be triacetylisothebenine when the same sequence of reactions was carried out on (—)-l-bromo-sinomeninone. /sothebenine is probably 4 6-dihydroxy-3-methoxy-5-(/3-methylaminoethyl)-phenanthrene [lxxxh], or the 4 7-dihydroxy-isomer [64], On heating with sodium hydroxide and methyl alcohol at 80° C., 1-bromotriacetyKsothebenine yields a compound C2oH2004NBr in 7 per cent, yield this is probably 1 -bromo-N-acetylisothebenine [55] (see also Chap. XXV). 

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