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Acetic acid, anhydride protection with

So why ATP First, we want a compound with intermediate hydrolysis energy so it can pick up energy from some reactions and deliver to others. Second we want a kinetically stable molecule which is thermodynamically unstable. Thus acetic acid anhydride would not work it is thermodynamically unstable to hydrolysis, but it is also kinetically unstable, with the carbonyl carbons wide open to water attack. Phosphoric acid anhydride is equally unstable, but is is sterically protected from water attack - in order to react quickly we need a catalyst -perfect. [Pg.259]

C2-homologizati on of sugars with, 264-265 Acetamide, JV-bromo- (AcNHBr, NBA) bromohydrination with, 275-276, 287 Acetaminophen (= paracetamol), 301 Acetate, piperidinium cat. for aldol add., 82 —, sodium a-epimerization of ketones, 277 opening of oxiranes, 282 Acetic acid, anhydride (AcfO) protection with. See Protection Pummerer rearr. with, 51, 265 —, esters (See also Protection of hydroxy groups) C-H acidity, 10 1-methylethenyi ester pr., 174 transenolization, 58 —, bromo-, esters pr., 179 a2-synthon, 19, 65, 309 d2-synthon, 19, 301 —, chloro-, esters pr., 179 hydantoins from, 308 —, cyano-, esters pr., 177 pyrrolines from, 298 —, (dialkoxyphosphinyl)-, esters pr 188 Wittig-Horner olefinations, 267, 282 —, diazo-, ethyl ester pr, 176, 178 cyclopropanes from, 74—75 —, dichloro- deblocking of pixyl ethers, 342 —, hydroxy-, esters pr., 176 —, hydroxyphenyl-, (S)- (l-mandelic acid) ... [Pg.199]

The solid appears to be a mixture of the complexes CH,COOH.BF, and 2CH COOH.BF,. The latter appears to be a liquid and is alone soluble in ethylene dichloride the former is a solid. The solid moiioocetic acid complex is obtained by saturating an ethylene dichloride solution of acetic acid with boron trifluoride, filtering and washing the precipitate with the solvent it is hygroscopic and should be protected from moisture. It may be used as required 0-75 mol is employed with 0-26 mol of ketone and 0 6 mol of anhydride. [Pg.865]

The 5-(aminomethyl)thiophene-2-acetic acid isomer 76 was prepared by chloromethylation in position 2 of thiophene followed by nucleophilic displacement with phthalimide to afford 81, and a second chloromethylation in position 5 to give 82 (Scheme 23). Subsequent reaction with cyanide gave 83, the hydolysis of which afforded the phthalide-protected amino acid 84 which was coupled to H-Ala-Ile-Gly-OMe using propanephosphoric anhydride, followed by hydrazine N-deprotection)110 ... [Pg.628]


See other pages where Acetic acid, anhydride protection with is mentioned: [Pg.259]    [Pg.42]    [Pg.119]    [Pg.258]    [Pg.623]    [Pg.367]    [Pg.320]    [Pg.387]    [Pg.75]    [Pg.4]    [Pg.9]    [Pg.541]    [Pg.650]    [Pg.204]    [Pg.44]    [Pg.72]    [Pg.152]    [Pg.82]    [Pg.108]    [Pg.121]    [Pg.180]    [Pg.221]    [Pg.237]    [Pg.268]    [Pg.94]    [Pg.658]    [Pg.1053]    [Pg.1357]    [Pg.338]    [Pg.352]    [Pg.437]    [Pg.447]    [Pg.448]    [Pg.106]    [Pg.659]    [Pg.558]    [Pg.353]    [Pg.497]    [Pg.403]    [Pg.45]    [Pg.147]   


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Acetals, protection

Acetic anhydride with acetals

With acetic anhydride

With anhydrides

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