4,5-dihydro- -chloride

Chemical Name 3-(2-Morpholinoethvlamino)-4-methvl-6-phenvlpyridazine dihydro-chloride... 

If the hydrochloric acid is added all at once instead of in two portions as detailed, a solid will be obtained consisting of o-tolidine coated with its dihydro-chloride, and the diazotisation will proceed slowly. 

C1C(=NH)NH2.HN03 mw 141.52, OB -11.3% colorless crysts, mp 120 expl at higher temp soly in w 7.9% at 0° and 22.2% at 30°. Prepd by treating cyanamide dihydro-chloride in w with aq AM or from tech Ca cyanamide (Ref 2), also by adding cooled coned nitric acid to very cold cyanamide in HCl (Ref 3)... 

Frydman et aZ. reported the sjmthesis of ethyl 5-methoxy-6-azagramine-2-carboxylate, isolated in 75% yield as the dihydro-chloride. 

Phenazarsinium 10-Amino-10-methyl-5,10-dihydro- (Chlorid) XIII/8, 366f. 

A solution of 24.3 g. (0.125 mole) of piperazine hexahydrate in 50 ml. of absolute ethanol, contained in a 250-ml. Erlenmeyer flask, is warmed in a bath at 65° as there is dissolved in the solution, by swirling, 22.1 g. (0.125 mole) of piperazine dihydro-chloride monohydrate (Note 1). As warming in the bath at 65° is continued, there is added during 5 minutes, with vigorous swirling or stirring, 15.8 g. (14.3 ml., 0.125 mole) of recently distilled benzyl chloride. The separation of white needles commences almost immediately. After the solution has been stirred for an additional 25 minutes at 65°, it is cooled, and the unstirred solution is kept in an ice bath for about 30 minutes. The crystals of piperazine dihydrochloride monohydrate are collected by suction filtration, washed with three 10-ml. portions of ice-cold... 

Amino-5-hydrazi no- 1,2,4 triazole Dihydro-chloride, HjN-HN-C-NH-N + 2HC1,... 

The dihydro-chloride salt of 2,7-bis(2-(diethylamino)ethoxy)-fluoren-9-one, referred to as tilorone hydrochloride (non-proprietary name) or bis-DEAE-fluorenone, is a broad spectrum antiviral compound44) with antitumor activity45-47). Mayer and coworkers48 49) have identified this compound as an interferon inducer and established a relationship with the antiviral activity. However, recently a lack of correlation between interferon induction and viral protection by tilorone hydrochloride has been reported50). 

Imino-2-phenyl-2,3-dihydro- -chlorid 945 3-Phenyl- -perchlorat 943... 

A/-(l-naphthyl)ethylenediamine dihydro chloride. Purple spots appear in a few minutes. 

The free diamine may also be converted into the dihydro-chloride, and the salt purified as follows The crude o-phenylene-diamine is dissolved in a mixture of 90-100 cc. of concentrated hydrochloric acid (sp. gr. 1.19) and 50-60 cc. of water containing 2-3 g. of stannous chloride, and the hot solution is treated with decolorizing charcoal. To the hot, colorless filtrate is added 150 cc. of concentrated hydrochloric acid, and the mixture is cooled thoroughly in an ice-salt bath. The colorless crystals are filtered by suction, washed with a small amount of cold concentrated hydrochloric acid, and dried in vacuum over solid sodium hydroxide. The yield of 0-phenylenediamine dihydrochloride is... 

Biphenyl)-4,4 -diamine, 3,3 -dichloro-, dihydro-chloride. AI3-22046 Benzidine, 3,j-dichloto-, dihydrochloride (1,T-Biphenyl)-4,4 -diamine, 3,3 -dichloro-, dihydro-chloride CCRIS 5899 3,3 -Dichlorobenzidine dihydrochloride EINECS 210-323-0 HSDB 5715 NSC 3524. 

AI3-50162 Alamon Atarax Atarax dihydrochloride Ataraxoid dihydroohloride Aterax Aterax dihydro-chloride Durrax EINECS 218-586-3 Hydroxyzine dihydroohloride Hydroxyzine hydrochloride Marax Neurolax Orgatrax Quiess QYS Tran-Q dihydro-chloride Tranquizine dihydroohloride Vistaril Parenteral Vistaril steraject. A Hi receptor antagonist. Anxiolytic antihistaminic. Has been used as a minor tranquillizer. Crystals mp = 193° soluble in H2O (<70 g/100 ml), CHCI3 (6 g/100 ml), MezCO (0.2 g/100 ml), EtzO (< 0,01 g/100... 

In some instances a carbon-carbon bond can be formed with C-nucleophiles. For example, 3-carboxamido-6-methylpyridazine is produced from 3-iodo-6-methylpyridazine by treatment with potassium cyanide in aqueous ethanol and l,3-dimethyl-6-oxo-l,6-dihydro-pyridazine-4-carboxylic acid from 4-chloro-l,3-dimethylpyridazin-6-(lH)-one by reaction with a mixture of cuprous chloride and potassium cyanide. Chloro-substituted pyridazines react with Grignard reagents. For example, 3,4,6-trichloropyridazine reacts with f-butyl-magnesium chloride to give 4-t-butyl-3,5,6-trichloro-l,4-dihydropyridazine (120) and 4,5-di-t-butyl-3,6-dichloro-l,4-dihydropyridazine (121) and both are converted into 4-t-butyl-3,6-dichloropyridazine (122 Scheme 38). 

Pyrimido[4,5- f]pyrimidines may be used as pyrimidine precursors. Thus, the dihydro derivative (736) undergoes alkaline hydrolysis to the amide (737 R = PrCO) which may be deacylated in ethanolic hydrogen chloride to give 5-aminomethyl-2-propylpyrimidin-4-amine (737 R = H) (64CPB393) rather similarly, the pyrimidopyrimidinedione (738) reacts with amines to give, for example, 6-amino-5-benzyliminomethyl-l,3-dimethylpyrimidine-2,4(lFf,3Ff)-dione (739 R = CH2Ph) or the hydrazone (739 R = NH2) (74JCS(Pl)1812). 

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