Diethylpropion dosing

Figure 3 presents the mean levels of self-infusion for the 14 phenylethyl-amines shown in figure 1. Of all the drugs tested, injection rates were... 

Diethylpropion is available as both an immediate-release and a controlled-release product. In conjunction with a reduced-calorie diet and/or exercise, dose diethylpropion (immediate-release) 25 mg three times a day before meals or 75 mg (controlled-release) once a day, usually midmorning.40... 

Take the last dose of diethylpropion in the early morning to avoid insomnia... 

FIGURE 7—48. Heroic combo 4 High-dose venlafaxine plus stimulant. Here, 5HT and NE are single-boosted and DA is double-boosted. The stimulants could include (/-amphetamine, methylphen-idate, phentermine, or diethylpropion. It could also include direct-acting dopamine agonists such as pramipexole. 

Anorectic drugs act mainly on the satiety centre in the hypothalamus (1). They also have metabohc effects involving fat and carbohydrate metaboUsm. Most of them are structurally related to amfetamine and increase physical activity. Their therapeutic effect tends to abate after some months, and part of this reduction in effect may be due to chemical alterations in the brain. Fenfluramine commonly produces drowsiness in normal doses, but has stimulaut effects in overdosage. Dexamfetamine, phenmetrazine, and benzfetamine all tend to cause euphoria, with a risk of addiction. Euphoria occasionally occurs with amfepramone (diethylpropion), phentermine, and chlorphentermine, but to a much lesser extent. Some adverse effects are due to sympathetic stimulation and gastrointestinal irritation these may necessitate withdrawal but are never serious. There are interactions with monoamine oxidase inhibitors and antihypertensive drugs. 

A dose-dependent increase, in electrical stimulation of the lateral hypothalamus, necessary to elicit eating in food-satiated rats, was clearly shown for amphetamine, phenmetrazine (III), metham-phetamine (IVa), chlorphentermine (Via) and diethylpropion (VII). 

Two diethylpropion analogues (VIII) and (IX) have been described. The thiophene derivative (VIIl) and related amino modifications were claimed to have anorexigenic activity comparable to amphetamine with much less CNS stimulation. A chloro-substituted derivative (IX) [SKF-709h8, FWH-h9h) was reported to be one-fifth as potent as diethyl-propion in decreasing food intake in dogs it produced less motor stimulation in the mouse than d-amphetamine, reversed and prevented reserpine induced depression. In the anesthetized cat, a biphasic blood pressure response was observed.22 A clinical trial of (IX), at daily doses of 75-150 mg, revealed effects similar to those obtained with diethylpropion.23 A clinical study designed to demonstrate the effect of continuous versus intermittent administration of diethyl-prop ion was shown to favor continuous administration.2A A related... 

Bupropion hydrochloride f/c tablets 150 mg. Adult dose 150-300 mg for 7-9 weeks (smoking cessation). In severe cases of depression, up to 450 mg of the hydrochloride salt have been recommended. Diethylpropion (diethylcathinone) is the N,N-diethyl derivative without the presence of the chlorine atom and displays amfetamine-like effects in humans. When... 

Diethylpropion hydrochloride tablets 25 mg. Adult dose 25 mg three times daily. 

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