Diethylenetriaminepenta

Diethylenetriaminepenta (methylene phosphonic acid) [DETPMP] is the most effective sequestrant for barium sulfate. DETPMP has a sequestration value of 820 mg CaC03/g product at pH 11. The hexa-sodium salt has MW of 705. Examples include Dequest 2066 and Mayoquest 1860. 

Interestingly, after intravenous administration of a radiolabelled folate conjugate ( -In-dium-diethylenetriaminepenta acid (DTPA)-folate) in the rat, the conjugate was rapidly excreted in the urine. Moreover, after intravenous administration to athymic mice with a human tumour cell implant, the radiotracer was not only taken up by the subcutaneous tumour but was also taken up by the kidneys in significant quantities [63], indicating substantial renal selectivity of the folate conjugate. In addition to the kidney, the liver also has a high concentration of the folate-receptor [64]. 

The three most commonly used phosphonates are diethylenetriaminepenta (methylenephosphonic acid) (DTPMP), ethylenediaminetetra(methylenephospho-nic acid) (EDTMP), and hydroxyethyldiphosphonic acid or etidronic acid (HEDP) (Figure 10.3). DTPMP and EDTMP are also powerful chelants that complex strongly with most metal ions to form six-coordinate complexes, and for this reason are often... 

Diethylenetriaminepenta-acetic acid [67-43-6] M 393.4, m 219-220 . Crystd from water. Dried under vacuum or at 110°. [Bielski and Thomas JACS 109 7761 1987. ... 

The Fe-EDTA complex catalysed the oxidation of tryptophan and the hydroxyla-tion of salicylate in the presence of a superoxide-generating system, A partial inhibition by diethylenetriaminepenta-acetate was observed for the latter reaction and in the ethylene production from 2-keto-4-thiomethylbutyrate... 

The production of hydroxyl radicals was demonstrated by spin-trapping in the autoxidation at pH 11.5 of 6-hydroxydopamine. The reaction was partially inhibited by SOD, by catalase, and by diethylenetriaminepenta-acetate and deferoxamine... 

The insulin producing P cells of the pancreas are selectively destroyed by alloxan, which is reduced there to dialurate. Isolated pancreatic islets of mice were protected against the action of alloxan, by BESOD, by catalase, and by scavengers of OH radicals. A treatment of rat pancreatic islets with SOD, catalase or diethylenetriaminepenta-acetate attenuated the effect of alloxan, suggesting again a participation of OH radicals... 

Schwarzenbach developed complexometric titrations with multidentate ligands such as nitrilotriacetate N(CH2C02)i3 and the potentially sexidentate (two N and four 0) ethylenediaminetetra-acetate and potentially octadentate (three N and five 0) diethylenetriaminepenta-acetate. Such synthetic amino-acids form strong com-... 

Another hepatocyte-specific contrast formulation, dysprosium ethoxybenzyltris(carboxylatomethyl)triazaun-decanedioic acid diethylenetriaminepenta-acetic acid (Dy-EOB-DTPA), has been used for Uver CT imaging (266). It contains calcium-EOB-DTPA (0.5 mg/ml), tro-metamol (1.2 mg/ml), and hydrochloric acid (final pH 7.4). It has been described as a stable metal chelate with high tolerability in vitro and in animal studies, in which a long-lasting increase in CT density of about 30 Hounsfield units has been reported. A total of 40 healthy male volunteers (mean age 33 years) received intravenous infusions... 

Technetium compounds are the most widely used radiopharmaceuticals the highest excretion in breast milk occurs with sodium pertechnetate and the lowest with technetium diethylenetriaminepenta-acetic acid, which is rapidly excreted by the kidneys. Depending on the type of examination and the dose of radiopharmaceutical, the mother should be advised to withhold breastfeeding for 12-24 hours. Advice may also be required concerning external radiation when the mother holds the child. 

The selectivity of the method is improved by the use of masking agents, such as diethylenetriaminepenta-acetic acid (DTPA ), EDTA, or DCTA [70]. 

Conventional chelating agents as diethylenetriaminepenta-acetic acid, DTPA (Figure 1), remove much of the soluble actinide present in body fluids, but are almost totally ineffective in removing the actinide after it has left the circulation or after hydrolysis of the metal to form colloids and polymers (13, 14,... 

The most accurate way of assessing changes in the GFR is to measure the clearance of a compound that is freely filtered by the glomerulus but is neither secreted nor reabsorbed by the tubule. Radiolabeled sodium io-thalamate and diethylenetriaminepenta-acetic acid (DTPA) are substances commercially available for this purpose. 

Diethylenetriaminepenta-acetic acid Dissolvine D DTPA EINECS 200-652-8 Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)- Hamp-Ex Acid Monaquest CAI N,N-Bis(2-... 

Somatostatin receptors have a broad distribution in normal tissue as well as in a variety of human malignancies (e.g., small cell lung, brain, breast, pituitary, and endocrine pancreatic cancers). For this reason, octreotide, which binds to somatostatin receptors, was converted to a radionuclide-containing peptide by reacting the amino terminus with an active ester of diethylenetriaminepenta acetic acid (DTPA) to give DTPA-octreotide and then chelated to the radionuclide ln (Fig. 7.14). This radiopharmaceutical is used as a diagnostic agent for the... 

In experimental work, the need often arises to maintain a predetermined concentration of a given metal ion, a concentration that is not allowed to rise above this level nor fall below it. This situation is met by the use of metal ion buffers which maintain a steady pM just as hydrogen ion buffers maintain a steady pH. With their help, free metal ions are replenished (as they are removed by the reaction) from a reservoir of bound metal complex. The first complexing agents to be used for this purpose were citrate and tartrate ions, but much more application has been found for ethylenediaminetetra-acetic acid (EDTA) (cf. 11.27), diethylenetriaminepenta-acetic acid (DTPA), and nitrilotriacetic acid (NTA). The necessary calculations will be found in Perrin and Dempsey (1974). 

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