Diethylenetriaminepenta-acetic acid

Diethylenetriaminepenta-acetic acid [67-43-6] M 393.4, m 219-220 . Crystd from water. Dried under vacuum or at 110°. [Bielski and Thomas JACS 109 7761 1987. ... 

Another hepatocyte-specific contrast formulation, dysprosium ethoxybenzyltris(carboxylatomethyl)triazaun-decanedioic acid diethylenetriaminepenta-acetic acid (Dy-EOB-DTPA), has been used for Uver CT imaging (266). It contains calcium-EOB-DTPA (0.5 mg/ml), tro-metamol (1.2 mg/ml), and hydrochloric acid (final pH 7.4). It has been described as a stable metal chelate with high tolerability in vitro and in animal studies, in which a long-lasting increase in CT density of about 30 Hounsfield units has been reported. A total of 40 healthy male volunteers (mean age 33 years) received intravenous infusions... 

Technetium compounds are the most widely used radiopharmaceuticals the highest excretion in breast milk occurs with sodium pertechnetate and the lowest with technetium diethylenetriaminepenta-acetic acid, which is rapidly excreted by the kidneys. Depending on the type of examination and the dose of radiopharmaceutical, the mother should be advised to withhold breastfeeding for 12-24 hours. Advice may also be required concerning external radiation when the mother holds the child. 

The selectivity of the method is improved by the use of masking agents, such as diethylenetriaminepenta-acetic acid (DTPA ), EDTA, or DCTA [70]. 

Conventional chelating agents as diethylenetriaminepenta-acetic acid, DTPA (Figure 1), remove much of the soluble actinide present in body fluids, but are almost totally ineffective in removing the actinide after it has left the circulation or after hydrolysis of the metal to form colloids and polymers (13, 14,... 

The most accurate way of assessing changes in the GFR is to measure the clearance of a compound that is freely filtered by the glomerulus but is neither secreted nor reabsorbed by the tubule. Radiolabeled sodium io-thalamate and diethylenetriaminepenta-acetic acid (DTPA) are substances commercially available for this purpose. 

Diethylenetriaminepenta-acetic acid Dissolvine D DTPA EINECS 200-652-8 Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)- Hamp-Ex Acid Monaquest CAI N,N-Bis(2-... 

Somatostatin receptors have a broad distribution in normal tissue as well as in a variety of human malignancies (e.g., small cell lung, brain, breast, pituitary, and endocrine pancreatic cancers). For this reason, octreotide, which binds to somatostatin receptors, was converted to a radionuclide-containing peptide by reacting the amino terminus with an active ester of diethylenetriaminepenta acetic acid (DTPA) to give DTPA-octreotide and then chelated to the radionuclide ln (Fig. 7.14). This radiopharmaceutical is used as a diagnostic agent for the... 

In experimental work, the need often arises to maintain a predetermined concentration of a given metal ion, a concentration that is not allowed to rise above this level nor fall below it. This situation is met by the use of metal ion buffers which maintain a steady pM just as hydrogen ion buffers maintain a steady pH. With their help, free metal ions are replenished (as they are removed by the reaction) from a reservoir of bound metal complex. The first complexing agents to be used for this purpose were citrate and tartrate ions, but much more application has been found for ethylenediaminetetra-acetic acid (EDTA) (cf. 11.27), diethylenetriaminepenta-acetic acid (DTPA), and nitrilotriacetic acid (NTA). The necessary calculations will be found in Perrin and Dempsey (1974). 

If the lignin is not removed in the bleaching process, as is usually the case with pulps with a high lignin content, such as mechanical, ground-wood and NSSC pulps, either reductive or oxidative chemicals are used for pulp brightening. Sodium dithionite is the most common reductive chemical in use today, and peroxides are commonly used if the process is oxidative. When chemothermomechanical pulp is bleached, additional chemicals such as sodium silicate or DTPA (diethylenetriaminepenta-acetic acid) are also used. 

Chelants at concentrations of 0.1-0.2% improve the oxidative stability through the complexation of the trace metal ions, e.g., iron, which catalyze the oxidative processes. Examples of the chelants commonly used are pentasodium diethylenetriaminepenta-acetic acid (DTPA), tetrasodium ethylenediaminetetraacetic acid (EDTA), sodium etidronate (EHDP), and citric acid. Magnesium silicate, formed in wet soap through the reaction of magnesium and silicate ions, is another chelant commonly used in simple soap bars. All of these chelants are usually added into the neat soap prior to the drying operation. 

The oxidation of cobalt(n) complexes with nitrilopolyacetic acid ligands, Y (edta, diethylenetriaminepenta-acetic acid, /ra/i5-l,2-cyclohexanediamine-tetra-acetic acid). 

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