Diethylamine agent

PoIyfluoFohalogenated oxiranes ate usually opened by nucleophilic reagents, for example alkoxides, at the central carbon atom However, an increase in the volume of the attacking agent, as in the case of diethylamine, directs the nucleophile toward the terminal carbon atom [dd] (equation 29)... 

Reaction of w-methylpiperazine with phosgene affords the carbamoyl chloride (170). Treatment of this intermediate with diethylamine affords the antiparasitic agent diethyl carbamazine (171)... 

In contrast to 6-azidobenzo[/)]thiophene, which yields only benzo[i]thiophen-6-amine (9 %) and JVh,Ar(1-diethylbenzo[/)]thiopheiie-6,7-diamine (25 % bp 175-177 C/0.7 Torr), 6-azido-2,3-dibromobcnzojhjthiophene (1 a, R = R2 = Br) on irradiation in diethylamine in the presence of pyrene, a triplet nitrene quenching agent, yields a mixture of 2,3-dibromo-./V6,./V6-diethyl-benzo[5]thiophene-6,7-diamine (2a, R1 = R2 = Br 13%) and the 8W-thieno[2,3-r]azepine 3a.14<1 Likewise, methyl 6-azidobenzo[6]thiophene-2-carboxylate (lb, R1 = C02Me R2 = H) yields the thienoazepine ester 3b.147... 

B. 2-Chloro-3,6-di-tert-butyl-l,4-benzoquirwne. A 2-1. Erlenmeyer flask is charged with a solution of 112 g. (0.385 mole) of 2,3-dichloro-2,5-di-fer<-butylcyclohex-5-ene-l,4-dione in 800 ml. of ether. A solution of 28.4 g. (0.383 mole) of diethylamine (N-ethylethanamine) in 50 ml. of ether is added in one portion to the vigorously swirled flask (Note 5). The reaction is instantaneous, resulting in a voluminous precipitate. The mixture is washed with two 1-1. portions of water and then with 500 ml. of aqueous saturated sodium chloride. The yellow ether solution is dried over anhydrous magnesium sulfate, the drying agent removed by filtration, and the solvent removed on a rotary evaporator to yield 96-97 g. (98-99%) of 2-chloro-3,6-di-ferf-butyl-l,4-benzo-quinone as a yellow oil which is used without further purification (Note 6). 

Changing the carbon disulfide trapping agent from copper acetate and diethylamine solution to methanolic potassium hydroxide to produce a xanthogenate increases the method s reproducibility and sensitivity. " ... 

Synthesis using TPABr as structure-directing agent and ammonia, water, hexanediamine, n-butylamine, diethylamine, ethylenediamine, or triethanolamine as base (seeds of TS-1 were added to get smaller crystallites and 100% crystallinity) Synthesis of fibrous titanosilicate... 

Water 5 J diethylamine must be removed from the paper before locating agents are used... 

The utility of a palladium catalyst in the synthesis of substituted aryl acetylenes is well established.(7,8,9,10) The end-capping agent I was produced by using a standard catalyst system, dichlorobls(triphenylphosphlne)palladlum (II)/copper (I) iodide/triphenylphosphlne mixture, which has been employed in previously developed ethynylation procedures.(10) The copper (I) iodide is believed to act as a cocatalyst, reducing the palladium (II) complex to the active palladium (0) catalyst. The scheme is shown in Figure 3 (diethylamine is the solvent).(11)... 

Amines such as diethylamine, morpholine, pyridine, and /V, /V, /V, /V -tetramethylethylene-diamine are used to solubilize the metal salt and increase the pH of the reaction system so as to lower the oxidation potential of the phenol reactant. The polymerization does not proceed if one uses an amine that forms an insoluble metal complex. Some copper-amine catalysts are inactivated by hydrolysis via the water formed as a by-product of polymerization. The presence of a desiccant such as anhydrous magnesium sulfate or 4-A molecular sieve in the reaction mixture prevents this inactivation. Polymerization is terminated by sweeping the reaction system with nitrogen and the catalyst is inactivated and removed by using an aqueous chelating agent. 

Sub-VX Diethyl ether, Dichloromethylphosphine, Ethyl alcohol, N,N-Diethylamine, 2-Ethylthioethanol, Rhombic sulfur Nerve agent... 

The inclusion of aromatic rings as part of the side chains results in quite potent agents, possibly because the rigid rings better define the position of the basic nitrogen. Reaction of para-hydroxyacetanilide (19-1) with formaldehyde and diethylamine affords the corresponding Mannich product (19-2) hydrolysis of the acetamide then leads to the aniline (19-3). Treatment of that compound with dichloro-quinoline (17-6) leads to the displacement of chlorine on the heterocyclic ring and the formation of amodiaquine (19-4) [21]. 

A comparison of various fluorinating agents in the preparation of fluoride 13, i.e. (2-chloro-1,1,2-trifluoroethyl)diethylamine and diethylaminosulfur trifluoride (R = H), tetrafluoro(phen-yl)-A5-phosphane (R = TMS), and potassium fluoride (R = Ts), has shown that the highest stereoselectivity is achieved with potassium fluoride and (2-chloro-l,1,2-trifluoroethyl)-diethylamine.19 The fluorination with tctrafluoro(phenyl)-7.5-phosphane proceeds, at least in part, via a carbocation and with a relatively low enantioselectivity.15... 

The highest oxidation state (+6) appears not to be the most stable one for the alkoxides. Uranium hexaethoxide is easily converted into pentaethoxide on action of different reducing agents such as ethylmercaptane, diethylamine, and soon. Its interaction with uranium tetraethoxide leads to coproportionation [856] ... 

TABLE 5 Effects of Flow Rate and Substituents on Chiral Resolution of Imidazole Antifungal Agents on Amylose CSPs Using Hexane-2-Propanol-Diethylamine (400 99 1, v/v/v) as the Mobile Phase... 

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