Dietary toxicity studies

Rohm Haas (1976) conducted a 90-day dietary toxicity study on rats fed monooctyltin trichloride at 0,... 

Lina, B., Korte, H., Nyman, L., and Unkila, M. 2005. A thirteen week dietary toxicity study with 7-hydroxsymatairesinol potassium acetate (HMR lignan) in rats. Regul. Toxicol. Pharmacol. 41, 28-38. 

Katz AC, Frank DW, Sauerhoff MW, et al. 1984. A 6-month dietary toxicity study of acidic sodium aluminum phosphate in beagle dogs. Food Chem Toxicol 22 7-9. 

Charles JM, Dalgard DW, Cunny HC, Wilson RD, and Bus JS (1996) Comparative subchronic and chronic dietary toxicity studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in the dog. Fundamental and Applied Toxicology 29(1) 78-85. 

Specific data on PBO is available in the areas of teratogenicity and fertility from studies performed in rats, mice and rabbits. Some background information is also available on the cllccts of long-term administration of PBO on reproductive tissues from chronic dietary toxicity studies performed in the rat and the dog. 

Comparison of results of dietary toxicity studies and estimated or calculated residues in avian food categories provide more than adequate margins of safety. As shown above, when a series of redundant worst-case assumptions arc made and the highest residue food item (short rangegrass) is used, the acute and chronic MOS values are 12.8 and 3.4, respectively (Tables 8.9 and 8.10). When actual residues (spinach) are used, the acute and chronic MOS values are 29 and 8.0, respectively. Further, when an additional conservative I Ox factor is applied to the exposure (i.e. 10 applications), the acute MOS values arc J-3 or greater. 

Liu, B., H. Asare-Anane, A. Al-Romaiyan, et al. 2009. Gharacterisation of the insulinotropic activity of an aqueous extract of Gymnema sylvestre in mouse beta-cells and human islets of Langerhans. Cell. Physiol. Biochem. 23 (1-3) 125-132. Ogawa, Y, K. Sekita, T. Umemura, et al. 2004. Gymnema sylvestre Leaf Extract A 52-Week Dietary Toxicity Study in Wistar Rats. /. Food Hyg. Soc. Jap. 45 (1) 8-18. 

Miyazawa, M., C. Miyahara, S. Satoh, and A. Sakai. 2003. Ninety-day dietary toxicity study of mulberry leaf extract in rats. Shokuhin Eiseigaku Zasshi 44(4) 191-197. 

Nikiforov, A.I., and A.K. Eajjen. 2008. A 90-day oral (dietary) toxicity study of rebaudioside A in Sprague-Dawley rats. Int.. Toxicol. 27(l) 65-80. 

Cox, G.E., Rucci, G. Babish, J.G. (1978) 90-day subacute dietary toxicity study of 78-002-2 in Sprague-Dawley rats. Unpublished report submitted to the Flavor and Extraot Manufacturers Association, Washington, DC, USA, by Food and Drug Researoh Laboratories, Inc. Submitted to WHO by the International Organization of the Flavor Industry, Brussels, Belgium. 

A 28-day dietary toxicity study was conducted in male and female CRL CD (SD) IGS BR rats that were fed a diet containing A/-3,7-dimethyl-2,6-octadienylcyclopropylcarboxamide at concentrations of 0, 11,110 or 1100 mg/kg. These dietary levels corresponded to measured daily intakes of 0, 0.92, 9 and 92 mg/kg bw and 0, 0.98, 10 and 97 mg/kg bw for males and females, respectively. Whereas 5 males and 5 females were included at the low- and mid-dose levels, the control and high-dose groups consisted of 10 males and 10 females. 

Hoxter, K. and G. Smith. 1993. B.t.t. Protein A Dietary Toxicity Study with Parasitic Hymenoptera (Nasonia vitripennis) Lab Project Number 139-349B WL-92436 93-081E. Unpubhshed study prepared by Wildlife International Ltd. 51 p. 

Campbell, S. I. Beavers, and M. Jaber. 1993. A Dietary Toxicity Study with Russet Burbank Potatoes in the Northern Bobwhite Lab Project Number 139-357 WL-93-12. Unpublished study prepared by Wildlife International Ltd. 50 p. 

Hoxter, K.and S. Lynn. 1992. Activated Btk HD-1 Protein A Dietary Toxicity Study With Ladybird Beetles Lab Project Numbers WL-92-156 139-321. Unpublished study prepared by Monsanto Co. and Wildlife Int l, Ltd. 23 p. 

Palmer, S. and J. Beavers. 1997. Cry9C Protein in Corn Pollen A Dietary Toxicity Study with the Ladybird Beetle (Hippodamia convergens) (Final Report) Lab Proj No. 452-101 452/102496/LBLC/SUB452. Unpublished study prepared by Wildlife International Ltd. 36 p. OPPTS 885-4350. ... 

Palmer, S. and H. Krueger. 1999. Bacillus thuringiensis Protein 11231 A Dietary Toxicity Study with Green Lacewing Larvae Chrysoperla cameo) Lab Project Number WL-98-298 16165. Unpublished study prepared by Monsanto Company and Wildlife International Ltd. 40 p. 

Hoxter, K. H. Krueger, and J. Porch. 1999. Cry IF Bacillus thuringiensis aar. aizawai Delta-Endotoxin A Dietary Toxicity Study with Green Lacewing Larvae Lab Project Number 354-115A. Unpublished study prepared by Wildlife International, Ltd. 28 p. OPPTS 885.4340 ... 

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