Heart failure diazoxide

THIAZIDES ANTIHYPERTENSIVES AND HEART FAILURE DRUGS-VASODILATOR ANTIHYPERTENSIVES Risk of hyperglycaemia when diazoxide is co administered with thiazides Additive effect both drugs have a hyperglycaemic effect Monitor blood glucose closely, particularly with diabetes... 

The potassium-channel openers are thought to work by opening a subset of K -channels, which leads to membrane stabilization. Agents such as this have so far been proposed as vasodilators for the treatment of hypertension or heart failure, e.g. nicorandil. They may, however, become used for their smooth muscle relaxant action at other sites, e.g. in the aihvays as ANTIASTHMATIC AGENTS, or for bladder hyperexcitability. Other examples of drugs that work at least partly by this mechanism are cromakalim, diazoxide, pinacidil and minoxidil. See POTASSIUM-CHANNEL ACTIVATORS. 

Multioi an damage An infant with persistent hyperinsulinemic hypoglycemia received diazoxide and developed pulmonary hypertension, heart failure, and neutropenia [119 ]. 

A girl with macrosomia, who was deUvered by cesarean section at 34 weeks, developed seizures and hypoglycemia in the first days of Ufe due to hyperinsuhnemia and was given octreotide and diazoxide. After 10 days she became short of breath with signs of heart failure and had evidence of pulmonary hypertension on echocardiography and cardiac catheterization. There was also neutropenia. Her respiratory... 

Yildizdas D, Erdem S, Kucukosmanoglu O, Yilmaz M, Yuksel B. Pulmonary h5fpertension, heart failure and neutropenia due to diazoxide therapy. Adv Ther 2008 25(5) 515-9. 

The most significant toxicity from diazoxide has been excessive hypotension, resulting from the recommendation to use a fixed dose of 300 mg in all patients. Such hypotension has resulted in stroke and myocardial infarction. The reflex sympathetic response can provoke angina, electrocardiographic evidence of ischemia, and cardiac failure in patients with ischemic heart disease, and diazoxide should be avoided in this situation. 

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