Diazinone

Compounds with organophosphate moieties, such as Diazinon, Methyl Parathion, Coumaphos and Glyphosate are usually hydrolyzed at the phosphoms atom (40,58). Indeed several Flavobacterium isolates are able to grow using parathion and diazinon as sole sources of carbon. 

Chlorfenvinphos, cythion, diazinon, elsan, fenitrothion, fenthion, malathion, methyl parathion, mevinphos, monocrotophos, parathion, quinalphos, temephos, TEPA, tetrachlorvinphos... 

Diaminotoluene, 50 Dianisidine, 50 Diatomaceous earth, 50 Diazepam, 50 Diazinon, 50... 

DIAZINON AG 600 WBC , diazinon, 50 DIAZOL , diazinon, 50 Diazomethane, 50 Dibenz(a,h)anthracene, 50 Dibenzofuran, 51 DIBK, 51 Diborane, 51 DIBROM , naled, 51 Dibromobenzene, 51 Dibromochloromethane, 51... 

Figure 15.13 Comprehensive two-dimensional GC chromatogram of a supercritical fluid exti act of spiked human semm. Peak identification is as follows 1, dicamha 2, tiifluralin 3, dicliloran 4, phorate 5, pentachlorophenol 6, atrazine 7, fonofos 8, diazinon 9, cWorothalonil 10, terhufos 11, alachlor 12, matalaxyl 13, malathion 14, metalochlor 15, DCPA 16, captan 17, folpet 18, heptadecanoic acid. Adapted imm Analytical Chemistry, 66, Z. Liu et al., Comprehensive two-dimensional gas chromatography for the fast separation and determination of pesticides exuacted from human senim , pp. 3086-3092, copyright 1994, with pemiission from the American Chemical Society.

Dichlorovos, phorate, dimethoate, diazinon, disulfoton, methyl-parathion, malathion, parathion, azinphos-methyl, azinphos-ethyl, and so on... 

Azinphos ethyl (h/ f 20-25), malathion (h/ f 40-45) and diazinone (h/ f 47-52) yielded white chromatogram zones on a blue background immediately. Before in situ quantitation the chromatogram was dried in the air until no film of moisture could be seen on the layer surface. It was then dried completely in a stream of warm air whereby the blue coloration of the background changed to brown (Fig. 1). The visual detection limits were 200 ng substance per chromatogram zone. 

Fig. 1 chromatogram of the thiophosphate insecticides (each ca. SOO ng) after treatment with dipping solutions I and II (A) before and (B) after complete drying of the TLC plate. TVacks 1 and S mixture Track 2 azinphos ethyl Track 3 malathion Track 4 diazinone. 

Fig. 2 Reflectance scan of a chromatogram track with 500 ng azinphos ethyl (1), 580 ng malathion (2) and 590 ng diazinone (3) per chromatogram zone.

Diazinon Acute oral LD50 Rat 450 Birds (mean 4 species) 4.5 100... 

The organophosphorons insecticides dimethoate and diazinon are mnch more toxic to insects (e.g., housefly) than they are to the rat or other mammals. A major factor responsible for this is rapid detoxication of the active oxon forms of these insecticides by A-esterases of mammals. Insects in general appear to have no A-esterase activity or, at best, low A-esterase activity (some earlier stndies confnsed A-esterase activity with B-esterase activity) (Walker 1994b). Diazinon also shows marked selectivity between birds and mammals, which has been explained on the gronnds of rapid detoxication by A-esterase in mammals, an activity that is absent from the blood of most species of birds (see Section 23.23). The related OP insecticides pirimiphos methyl and pirimiphos ethyl show similar selectivity between birds and mammals. Pyrethroid insecticides are highly selective between insects and mammals, and this has been attributed to faster metabolic detoxication by mammals and greater sensitivity of target (Na+ channel) in insects. 

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