Diazinon, dermal absorption

The use of a 2-day lag period from the time of diazinon application to the use of office or domestic indoor space appears adequate to eliminate exposure risks from vapors and residues that might be incurred from either inhalation or dermal absorption. Air sampling of a room treated with 36 pest control strips measured a maximum diazinon air concentration of 1.34 pg/m3 15 days postapplication (Jackson and Lewis 1981). Similarly, Williams et al. (1987) found that air sampling in two animal facility areas used by facility personnel and treated monthly with a 1% aqueous diazinon solution measured 2-3 pg/m3 less than 24 hours postapplication. Currie et al. (1990) also measured diazinon air concentrations in empty and... 

Moody RP, Nadeau B. In vitro dermal absorption of pesticides. IV. In vivo and in vitro comparison of the oiganophosphorus insecticide diazinon in rat, guinea pig, pig, human and tissue-cultured skin. Toxicol In Vitro. 1994 8 1213-8. 

No studies were located regarding absorption of diazinon after dermal exposure in animals. 

Rayner et al. 1972 Richter et al. 1992 Soliman et al. 1982 Stalberg et al. 1978), no comparative animal studies are available. There is a correlation in the data regarding the absorption, distribution, metabolism, and excretion of diazinon following oral doses in both animal and human studies (Abdelsalam and Ford 1986 Iverson et al. 1975 Janes et al. 1973 Machin et al. 1971, 1974 Mount 1984 Miicke et al. 1970 Poklis et al. 1980) however, comparative data on the distribution and metabolism of diazinon after inhalation or dermal exposure in humans or animals, or on the excretion of diazinon after dermal exposure in animals are not available. Further studies are required to fill these data gaps. 

Bioavailability from Environmental Media. Diazinon can be absorbed following inhalation, dermal, or oral exposures. Absorption through the skin is of major concern for exposures of farmers, farm workers, commercial applicators, or homeowners related to the use of diazinon as an insecticide or nematocide (Davis et al. 1983). Absorption via inhalation is a major concern particularly with respect to indoor exposures to diazinon within 2 days postapplication of the compound as a pest control agent in commercial buildings and homes (Currie et al. 1990 Jackson and Lewis 1981 Lenhart and Kawamoto 1994 Williams et al. 1987). Additional information on the concentrations of diazinon in indoor air and in groundwater from domestic wells, particularly from environments near hazardous waste sites, is needed to determine the bioavailability of diazinon in these media. 

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