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Dialysis, human plasma

R. Herraez-Heruandez, A. J. H. Eouter, N. C. van de Merbel and U. A. Th Brinkman, Automated on-line dialysis for sample preparation for gas cliromatogruphy determination of benzodiazepines in human plasma , 7. Pharm. Biomed. Anal. 14 1077-1087 (1996). [Pg.299]

In studies of mice, rats, and dogs, diisopropyl methylphosphonate was rapidly absorbed into plasma (Hart 1976). The plasma data indicate that all three species rapidly absorbed diisopropyl methylphosphonate, although the exact rate was species specific. Although no studies were located regarding human absorption, diisopropyl methylphosphonate is also likely to be absorbed rapidly into the plasma of humans. The ability of porous polymeric sorbents, activated carbon, and dialysis to remove diisopropyl methylphosphonate from human plasma has been studied (McPhillips 1983). The grafted butyl-XAD-4 was found to be the most efficient sorbent for the removal of diisopropyl methylphosphonate from human plasma. Hemoperfusion of plasma over synthetic XAD-4 or butyl-XAD-4 sorbent resin was more efficient than dialysis/ultrafiltration for the removal of diisopropyl methylphosphonate from human plasma the smaller surface of the packed resins provided less area to minimize damage to molecular constituents of the plasma. These methods are useful in reducing diisopropyl methylphosphonate concentrations in the plasma. However, since diisopropyl methylphosphonate and its metabolites are not retained by the body, the need for methods to reduce body burden is uncertain. [Pg.101]

Methods for Reducing Toxic Effects. Little information is available regarding reducing the toxic effects of diisopropyl methylphosphonate following exposure. Recommended treatments include general hygienic procedures for rapid decontamination. The ability of porous polymeric sorbents, activated carbon, and dialysis to remove diisopropyl methylphosphonate from human plasma has been studied. However, since diisopropyl methylphosphonate and its metabolites are not retained by the body, the need for methods to reduce body burden is uncertain. [Pg.109]

By the dialysis method, the protein binding of moxalactam was 43 percent and by the agar-diffusion method, 40 percent (6). By an ultrafiltration method, the binding of moxalactam in pooled fresh human plasma was 50.7 percent at physiologic temperature and pH (38). [Pg.320]

Analytical column and post column immobilized enzyme reactor supplied as part of a ACh/Ch assay kit. Sodium phosphate buffer pH 8.5 containing Kathon CG (Rohm and Haas, PA, USA), [1 mL/min]. Electrochemical at + 0.5 V versus Ag/AgCl. Human plasma and peritoneal dialysis effluent. [185]... [Pg.93]

Swinkels LM, Ross H, Benraad TJ. A symmetric dialysis method for the determination of free testosterone in human plasma, Clin Chem Acta 1978 165 341-9. [Pg.2150]

Andresen, A.T. Rasmussen, K.E. Rugstad, H.E. Automated determination of free phenytoin in human plasma with on-line equilibrium dialysis and column-switching high-performance liquid chromatography. J.Chromatogr., 1993, 621, 189-198... [Pg.1132]

Mn Tracer technique, equilibrium dialysis Human or rabbit plasma Nandedkar et al. (1973)... [Pg.195]

Cherti, N. Kinowski, J.M. Lefrant, J.Y. Bressolle, F. High-performance liquid chromatographic determination of cefepime in human plasma and in urine and dialysis fluid using a column-switching technique. J. Chromatogr. B, 2001, 754, 377-386. [Pg.215]

Ksirlsson, M. Korkolainen, T. Wikberg, T. Automated analysis of levosimendan in human plasma by on-line dialysis and liquid chromatography, Biomed.Chromatogr., 1997,11, 54-58. [Pg.349]

Muxlow, A.-M. Fowles, S. RusseU, P. Automated high-performance liquid chromatography method for the determination of rosiglitazone in human plasma, J.Chromatogr.B, 2001, 752, 77-84. [dialysis fluorescence detection LOQ 3 ng/mL]... [Pg.567]

All the techniques described in this chapter contribute to improved metabolite characterization. Notably, these techniques will enable the generation of extended time profiles for plasma radioactivity, the assessment of free metabolite concentrations following plasma dialysis, and the characterization of metabolites at very low levels of exposure, for example, following inhaled or dermal routes of administration. Furthermore, the use of high-sensitivity techniques could impact the design of radiolabel studies, for example, by enabling a lower radiolabel dose to be administered to human subjects without compromising the ability to characterize the metabolic fate of the compound of interest. [Pg.268]

Dialysis of carbonic anhydrase against a zinc chelate, 2,6-pyridinedicarboxylate, removes the active-site zinc leaving apo-carbonic anhydrase (Scheme 1) [35-37]. In our experiments [38], dialysis of carbonic anhydrase from bovine erythrocytes (a mixture of isoenzymes) against 2,6-pyridinedicarboxylate in acetate buffer at pH 5.5 removed 90-95 mol% of the zinc as shown by inductively coupled plasma atomic emission spectrometry (ICP-AES). This amount is similar to that removed previously for bovine [35-37] and human [39] carbonic anhydrase. Consistent with this removal of the active-site zinc, the apo-carbonic anhydrase lost 93-97% of the original catalytic activity for the hydrolysis of p-nitrophenyl acetate. Similar treatment of bovine carbonic anhydrase isoenzyme II (available commercially) and human carbonic anhydrase isoenzyme II gave the corresponding apo-enzymes. [Pg.51]


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See also in sourсe #XX -- [ Pg.194 , Pg.195 ]




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