Dexamethasone Theophylline

C3HjN20 96-31-1) see Theophylline dimorpholinophosphinic chloride (CgHi ClNiOgP 7264-90-6) see Dexamethasone phosphate Paramethasone Prednisolone sodium phosphate (llp,16a)-21-[(di-4-morpholinylphosphinyi)oxy]-9-fluoro-... 

Phenytoin Cortisol, dexamethasone, digitoxin, itraconazole, theophylline... 

Figure 6.17 The classification of 42 drugs in the (solubility-dose ratio, apparent permeability) plane of the QBCS. The intersection of the dashed lines drawn at the cutoff points form the region of the borderline drugs. Key 1 acetyl salicylic acid 2 atenolol 3 caffeine 4 carbamazepine 5 chlorpheniramine 6 chlorothiazide 7 cimetidine 8 clonidine 9 corticosterone 10 desipramine 11 dexamethasone 12 diazepam 13 digoxin 14 diltiazem 15 disopyramide 16 furosemide 17 gancidovir 18 glycine 19 grizeofulvin 20 hydrochlorothiazide 21 hydrocortisone 22 ibuprofen 23 indomethacine 24 ketoprofen 25 mannitol 26 metoprolol 27 naproxen 28 panadiplon 29 phenytoin 30 piroxicam 31 propanolol 32 quinidine 33 ranitidine 34 salicylic acid 35 saquinavir 36 scopolamine 37 sulfasalazine 38 sulpiride 39 testosterone 40 theophylline 41 verapamil HC1 42 zidovudine.

Aminoglutethimide [ah me no glue TETH i mide] is useful in second line therapy for the treatment of metastatic breast cancer. It inhibits the adrenal synthesis of pregnenolone from cholesterol, and the extra-adrenal aromatase reaction responsible for the synthesis of estrogen from androstenedione. Aminoglutethimide is administered orally, and is metabolized by the hepatic cytochrome P-450 system to inactive products. Because of its ability to induce this system, its own metabolism is accelerated, and interactions that increase the metabolism of dexamethasone (see p. 275), theophylline (see p. 220) and digoxin (see p. 158) can occur. Aminoglutethimide causes transient CNS depression and a maculopapular rash. 

Noninterfering aminophylline, beclomethasone, cloprednol, dexamethasone, fenoterol, ipratropium bromide, methylprednisolone, orciprenahne, prednisolone, reproterol, limi-terol, salmeterol, sodium cromoglycate, theophylline... 

Noninterfering amoxicillin, ceiffeine, dexamethasone, gentamicin, hydrocortisone, indo-methacin, metoclopramide, midazolam, theobromine, theophylline, tolazoline... 

Simultaneous acebutolol, acetazolamide, acetophenetidin, adrenosterone, aldosterone, amitriptyline, androsten-3,17-dione, aspirin, carbamazepine, cephalothin, chlorothiazide, dehydrocorticosterone, deoxycorticosterone, deo cortisol, desipramine, dexamethasone, diazepam, equilenin, estradiol, estriol, estrone, fluorometholone, furosemide, hydrochlorothiazide, hydroxycorticosterone, hydroxyprogesterone, hydroxyprogesterone, imip-ramine, indomethacin, methylhydroxyprogesterone, methylprednisolone, nandrolone, nordiazepam, nortriptyline, pheniramine, phenobarbital, phenytoin, prednisolone, prednisone, primidone, probenecid, progesterone, quinine, spironolactone, testosterone, theophylline, triamcinolone, tripelennamine... 

Noninterfering amikacin, amoxicillin, dexamethasone, gentamicin, indomethacin, morphine, phenobarbital, theophylline, vitamins... 

Simultaneous acetaminophen, aldosterone, allopurinol, amitriplyline, caffeine, calcitriol, cephalothin, chlordiazepoxide, chlorothiazide, corticosterone, cortisone, dexamethasone, diazepam, ephedrine, ethinyl estradiol, furosemide, hydrocortisone, ibuprofen, imipra-mine, indomethacin, mechlorethamine, methylprednisone, metolazone, nandrolone, naproxen, phenacetin, phenobarbital, phen3doin, probenecid, progesterone, propranolol, sulfasalazine, testosterone, theophylline, vincristine... 

Epinephrine and isoproterenol (via cAMP mechanisms) and theophylline (via cAMP or block of adenosine receptors) inhibit the release of mediators from mast cells and basophils and cause bronchodilation. Diphenhydramine competitively blocks histamine actions at H, receptors, actions that would otherwise cause bronchoconstriction and increased capillary permeability. Dexamethasone has multiple cellular effects, including inhibition of IgE-producing clone proliferation, block of T helper cell function, and anti-inflammatory actions. Most of the actions of glucocorticoids result from decreases in the synthesis of cytokines (eg, interleukins, platelet activating factor) or eicosanoids (leukotrienes, prostaglandins). 

B7. Beck, W. T., Bellantone, R. A., and Canellakis, E. S., The in vivo stimulation of rat liver ornithine decarboxylase activity by dibutyiyl cyclic adenosine 3, 5 -monophosphate, theophylline and dexamethasone. Biochem. Biophys. Res. Commun. 48, 1649 (1972). 

Brocks SM, Sholiton U, Weric EE, Altenau P. The effects of ephedrine and theophylline on dexamethasone metabolism in bronchial asthma. 1977) 17, 308-18. 

In one study it was briefly mentioned that theophylline did not appear to affeet dexamethasone metabolism. ... 

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