Development of Influenza Virus Sialidase Inhibitors

Mauro Pascolutti, Robin J. Thomson, and Mark von Itzstein 

Lead Generation Methods, Strate es, and Case Studies, First Edition. Edited by Jdrg Holenz. 

While the preparation of annual vaccines against type A and B influenza is a well-developed process, the vaccines are neither universally effective [6] nor administered [14]. Therapeutic agents are, therefore, an important line of defense against influenza, particularly where vaccines have limited efficacy or are under development, and in cases of severe infection [6,15]. 

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Further Developments of Influenza Virus Sialidase Inhibitors. 123... 

X-ray crystal structures of a-Neu5Ac and 11 in complex with influenza virus sialidases in the 1980s and early 1990s led to the opportunity for structure-based design and development of influenza virus sialidase inhibitors [66, 85],... 

Several excellent articles describing various aspects of influenza virus, both with respect to the virus itself as well as approaches towards the development of anti-influenza agents, have been published in recent years [4-16]. In view of the comprehensive nature of these reports it is the aim of this account, apart from providing the background information necessary to a fundamental understanding of influenza, to focus on advances in the development of influenza virus sialidase inhibitors over the last decade. ... 

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