Sialidases inhibitors

Anti-Influenza Drugs The Development of Sialidase Inhibitors... 

Further Developments of Influenza Virus Sialidase Inhibitors. 123... 

Fig. 3 Sialidase inhibitor Neu5Ac2en 4 bound in the active site of influenza A virus sialidase (from PDB structure IfSb (Smith et al, 2001)), Left Stick model of 4 surrounded by some important active site residues. Right Electrostatic potential surface rendering of the active site (blue -positive, red - negative), (Amino acid numbering for influenza A/N2 sialidase is used throughout this review)...

In the following sections, an overview of some of the key developments in the discovery of potent influenza vims sialidase inhibitors is provided. In the first instance, the discovery of the influenza vims sialidase inhibitors that have become the current first-hne-of-defence anti-influenza dmgs will be described, followed by a description of some of the other important sialidase inhibitor developments to date. 

Table 2 Sensitivity of influenza virus sialidase variants isolated in the clinical setting to sialidase inhibitors in sialidase assays ...

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