Development and reproductive toxicology

Faroon OM, Keith S, Jones D, and deRosa C (2001) Effects of polychlorinated biphenyls on development and reproduction. Toxicology and Industrial Health 17 63-93. 

DART/ETIC (Development and Reproductive Toxicology/Environmental Teratology Information Center)... 

Hood RD, MiUer DB (2006) MaternaUy-mediated effects on development. In Hood RD (ed) Developmental and reproductive toxicology, a practical approach, 2nd edn. CRC, Boca Raton, pp 93-124... 

The Developmental and Reproductive Toxicology (DART) Technical Committee at HESI has been continually active in the development of alternative tests by providing a forum to exchange information and data and by its organizational framework to pool resources for collaborative efforts. 

Nina Holland is an associate adjunct professor of genetics and toxicology and director of the biorepository at the University of California, Berkeley School of Public Health. Her scientific interests include molecular epidemiology of children s health, cytogenetics, and reproductive toxicology. In Dr. Holland s Laboratory of Children s Environmental Health, research focuses on the development and implementation of genetic and immuno-... 

Hood RD, Miller DB. Maternally mediated effects on development. In Developmental and Reproductive Toxicology. New York, NY CRC Press 2006 101-102. 

Weinbauer GF.The nonhuman primate as a model in developmental and reproductive toxicology. In Primate Models in Pharmaceutical Drug Development, edited by Korte R, Vogel E, and Weinbauer GF, pp. 49-64. Munster, Germany Waxmann Press, 2002. 

The American Petroleum Industry is currently sponsoring research on the toxicology of hydrogen sulfide. These studies include examinations of neurotoxicology, reproductive and developmental toxicology (including developmental neurotoxicity), and the development of a PBPK model. 

In recent years, concern that chemicals might inadvertently be disrupting the endocrine system of humans and wildlife has increased. The concerns regarding exposure to these endocrine disrupters are based on adverse effects observed in certain wildlife, fish, and ecosystems increased incidences of certain endocrine-related human diseases and adverse effects observed in laboratory animals exposed to certain chemicals. The main effects reported in both wildlife and humans concern reproductive and sexual development and function altered immune system, nervous system, and thyroid function and hormone-related cancers. Endocrine dismption is not considered a toxicological endpoint in its own right, but a functional change or toxicological mode(s) of action that may lead to adverse effects. Endocrine dismpters are addressed further in Section 4.11. 

Reproductive toxicology, usually embryo/ foetal development studies in two species, is required in Europe and Japan if women of childbearing potential are included. Not required in the United States for some early trials... 

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