Design biotechnology

Schneider G, So SS. Adaptive Systems in Drug Design (Biotechnology Intelligence Unit 5). Georgetown Landes Bioscience 2002. p.45-7. 

Keywords Experimental design Plackett-Burman design Factorial design Biotechnological process Acrylic acid Structured model... 

How to design sequences tliat adopt a specified fold [9] This is tire inverse protein folding problem tliat is vital to the biotechnology industry. There are some proteins tliat do not spontaneously reach tire native confomiation. In tire cells tliese proteins fold witli tire assistance of helper molecules referred to as chaperonins. The chaperonin-mediated folding problem involves an understanding of tire interactions between proteins. 

Guner O F (Editor) 2000. Pharmacophore Perception, Development, and Use in Drug Design. International University Line Biotechnology Series, 2. 

Aside from designs and plants, inventions are required to exhibit usefiilness or utiHty to be patentable. In fact, issued patents for processes, machines, compositions, and articles are often commonly referred to as "utiHty" patents. Depending on the nature of the technology, a single assertion of utiHty may suffice. In other cases, such as in the field of biotechnology, a more elaborate demonstration of utiHty may be necessary. Although utiHty maybe supported by an assertion of use, appHcation, or benefit, the assertion must be accurate and credible to ensure the enforceabiHty of any patent reHed upon to cover the invention. 

Bioprocess Control An industrial fermenter is a fairly sophisticated device with control of temperature, aeration rate, and perhaps pH, concentration of dissolved oxygen, or some nutrient concentration. There has been a strong trend to automated data collection and analysis. Analog control is stiU very common, but when a computer is available for on-line data collec tion, it makes sense to use it for control as well. More elaborate measurements are performed with research bioreactors, but each new electrode or assay adds more work, additional costs, and potential headaches. Most of the functional relationships in biotechnology are nonlinear, but this may not hinder control when bioprocess operate over a narrow range of conditions. Furthermore, process control is far advanced beyond the days when the main tools for designing control systems were intended for linear systems. 

Biotechnology by Open Fearning, Bioreactor Design and Product Yield, Butterworth-Heinemann, ISBN 07506-15095, 1992. 

The BIOTOL series of texts are designed to provide a self-study resource concerning the principles, practices and applications of biotechnology. This text is designed to explain how biotechnology may be applied to solve problems encountered in the production and use of organic chemicals in a wide range of business sectors. 

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