Derris malaccensis

Takashima, J. et al., Derrisin, a new rotenoid from Derris malaccensis plain and a.nti-Helicobacter pylori activity of its related constituents. Journal of Natural Products, 65, 611, 2002. 

Dermonistat, 784 Dermoval, 476 Dermovaleas, 393 Dermovat(e), 476 Dermoxin, 476 Derris, 963 Derris elhptica, 963 Derris malaccensis, 963 Desace, 517... 

DERRIS Derridis radix The drug consists the dried roots of Derris elliptica (Wallich) Benth. and Derris malaccensis Prain, family Fabaceae these Derris species grow in South East Asia, where they also are cultivated. They contain as active ingredient an iso-fla-vonoid rotenone, which has a pronounced insecticidal effect. Rotenone and similar substances have the great advantage that they do not leave any toxic residues. 

R=H, Elliptone (Derris elUptica) R=OH, Malaccol (Derris malaccensis ... 

Occurs in Derris malaccensis (Kinta type). Yellow prisms or neodle.s from CHClj-EtOH. M.p. 225°, solidifying and i-emelting at 244°. Spar. sol. EtOH, Me CO, CgHg. [a] 190° in... 

Isol. from Crotalaria burhia, Derris malaccensis, Millettia auriculata, Piscidia erythrina and Tephrosia toxicaria. Needles (EtOH or Me2CO). Spar. sol. dil. NaOH. Mp 174.5-177.5° (183-194°, 195-196°). [a] -184° (c, 1.335 in C H,). 

Obt. from Derris malaccensis. Occurs in Crotalaria burhia also D. elliptica, Tephrosia odorata and T. toxicaria. 

Another class of i. are rotenoids derived from the roots and seeds of Derris (Deguelia) elliptica and Derris malaccensis (Leguminosae) and over 60 other plant species. A most active compound is ro-tenone [83-79-4], a polycylic compound that can be applied to food crops shortly before use, due to its rapid degradation after exposure to sunlight. Rotenone-containing i. are applied as dust, powder or emulsions. 

Rotenone is the principal active insecticidal constituent of derris, the dried rhizome and roots of Derris elliptica, D. malaccensis (Leguminosae) and other species of Derris, and of lonchocarpus, the dried root of Lonchocarpus utilis, L. urucu and other species of Lonchocarpus (Leguminosae). 

Derr is or rotenone is a poisonous alkaloid that has long been used by indigenous peoples of Southeast Asia as arrow and fish poisons. Rotenone is now used widely as a rodenticide to kill small mammals and as an insecticide to kill pest insects. This chemical is mostly extracted from the plants Derris elliptica and D. malaccensis. 

Found in Crotalaria burhia, C. medicaginea, Derris elliptica, D. malaccensis, Lonchocarpus spp., Mundulea sericea, Piscidia mollis and Tephrosia spp. Some of these samples are the (—)-form, some the ( )-form and others have unreported opt. activity. 

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