Dermal exposure post-application

A more recent macro-event -based approach to post-application dermal exposure modehng involves the use of body-part-specific transfer factor (TF) point-estimates and/or underlying distributions. The unitless TFs represent an activity-specific basis for estimating dermal loading (g/cm ) for various anatomical regions from compound-specific transferable residue data (g/cm ). 

This study provides a means for conservatively estimating potential post-application dermal exposures to treated surfaces following the use of indoor total release foggers by using a high-contact, but reproducible activity. The procedure for estimating potential dermal exposure is based on the use of transfer factors (TFs) derived from the human volunteer dermal dosimetry and treated carpet transferable-residue measurements based on an indoor roller method (Ross et al, 1990, 1991). 

Secondary exposure (biocides) Post-application exposure via the enviromnent, namely bystanders and consumers, including children, who may be inadvertently exposed to wood preservatives by inhalation, dermal contact or by ingestion, and have little or no control over this exposure (OECD, 2000). 

Dermal eoqposure to residents to DDVP oouH not be assessed however, it was noted that the environmental eaqxjsure pads received 0.31910.183 pg/on /hr during the application u)d the two hrs post-initiation. This r esents 63.9% of the total dermal exposure of the applicators. 

Other Systemic Effects. In rabbits exposed dermally to isophorone at doses up to 3160 mg/kg, no systemic pathological effects were found by gross necropsy (Hazleton Labs 1964), but histological examinations were not performed. In this study, the site of application was occluded for 24 hours to prevent evaporation of isophorone from the skin. No significant differences between pre-exposure and post-exposure levels of serum electrolytes, blood glucose and sulfhydride radicals, SGOT,... 

---