Drug delivery dermal

Nanda, A. et al., Transferosomes a novel ultradeformable vesicular carrier for teans-dermal drug delivery. Drug Del. TechnoL, 5, 1, 2005. 

Prausnitz, M.R., et al. 1993. Electroporation of mammalian skin A mechanism to enhance trans-dermal drug delivery. Proc Natl Acad Sci USA 90 10504. 

M. Foldvari, A. Gesztes, and M. Mezei, Dermal drug delivery by liposome encapsulation, clinical and electron microscopic studies. J. Microsc. Encapsulation 7 479-489 (1990). 

Francoeur, M. L., Golden, G. M. and Potts, R. O. Oleic acid Its effects on stratum comeum in relation to (trans)dermal drug delivery. Pharmaceutical Research 1990 7(6) 621-627,1990. 

Trawi-dermal drug delivery has become one of the fastest growing systems for some disease treatments. It has been demonstrated that the skin can be used as a... 

The encapsulation of hepatocytes for a bioartificial liver, and cell therapy for the treatment of other hormone deficiencies or neurodegenerative diseases, such as Alzheimer s and Parkinson s, are also under investigation. Additional examples of cell encapsulation in polymer-polymer coacervates include non-autologous gene therapy,blood substitutes as well as the treatment of prostate cancer. Pharmaceutical applications of microcapsules encompass, in addition, trans-dermal drug delivery and protein delivery such as is required in anti-inflammatory therapy for arthritis. 

Most drugs do not penetrate epithelial barriers at rates sufficient for clinical usefulness without permeability enhancers, chemicals that are routinely added to dermal drug delivery products. 18 For example, using human skin in an in vitro study, it was demonstrated that sodium dichlofenac (K = 0.70) permeability was enhanced by a mixture containing the lipophiles oleic acid (K = 7.64) and c/-limonene (K = 4.57)J191... 

Keywords Dermal Drug delivery Permeability Skin Transdermal... 

Typical delivery systems can be utilised to achieve transdermal drug delivery or dermal drug delivery. The former involves the delivery of drugs through the skin... 

Passive Methods for Enhancing (Trans)dermal Drug Delivery... 

Brown, M.B. and Martin, G.P. (2005) Dermal drug delivery system . World Patent No. WO 2005058226. 

The biomembrane passage of a drug depends primarily on its physicochemical properties and especially on its partition coefficient (Chapters 22 and 34). Thus, the transient attachment of a lipophilic carrier group to an active principle can provide a better bioavailability, mostly by facifitating cell membrane crossing by passive diffusion. Peroral absorption, as well as rectal absorption, ocular drug delivery and dermal drug delivery, are dependent on passive diffusion. Finally, lipophilic carriers can sometimes be useful to reduce first-pass metabolism. ... 

Shukla, A., Krause, A. and Neubert, R.H.H. (2003) Microemulsions as colloidal vehicle systems for dermal drug delivery. Part IV Investigation of microemulsion systems based on a eutectic mixture of lidocaine andprilocaine as the colloidal phase by dynamic light scattering. /. Pharm. Pharmacol., 55, 741-748. 

Prausnitz MR (2004) Microneedles for trans-dermal drug delivery. Adv Drug Deliv Rev 56(5) 581-587... 

J. Tang, S. Cai, B. Katkade, W.c. Schumacher, and K.j. Miller, Trans-dermal drug delivery device, US Patent Application 20140 083 878, assigned to Mylan Inc., Morgantown (WV), March 27,2014. 

Guenther U, Smirnova 1, Neubert RH H (2(X)8) Hydrophilic silica aerogels as dermal drug delivery systems -Dithranol as a model drug. Eur Jo Pharmac Biopharmac 69 935 942... 

Jenning could show an increased loading of retinol into the NLC formulations compared to SLN. NLC formulations are currently intensively studied particularly for dermal drug delivery for, e.g., retinol, non-steroidal anti-inflammatory and antifungal drugs as well as for cosmetic formulations. Some cosmetic formulations based on NLC with camauba wax and black currant seed oil as solid and liquid lipid components, respectively, have already reached the market (NanoLipid Restore CLR and QIO CLR, Dr. Rimpler GmbH). 

SEN and NEC formulations are also intensively studied with respect to dermal drug delivery for a broad range of drugs. ° T28-i30,i59,i68,171,185,213 spite the diversity of... 

As for peroral administration the topical, in particular dermal administration poses much lower demands on the colloidal quality of the dispersions compared to a parenteral administration. Moreover, typical components like GMO or OA may serve as enhancers for drug penetration and permeation thus making dispersions based on these substances promising with regard to dermal drug delivery. 

The potential of CBNs has been documented in the arena of fields including immunization, topical/ocular/dermal drug delivery, transmucosal oral/nasal peptide absorption, anti-cancer drug delivery, brain delivery and gene delivery. Figure 4.2 summarizes... 

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