Anti-Inflammatory Therapy

Cytokines. Figure 2 Cytokines. Strategies directed against TNF or IL-1 in anti-inflammatory therapy. 

Patients with a good response to therapy should consider intensification of anti-inflammatory therapy.1 Although guidelines recommend doubling the previous inhaled corticosteroid dose, this may not be necessary for mild exacerba-tions.3,41,42 Treatment selection should be individualized based on what has worked for the patient previously. 

Cato AC, Schacke H, Sterry W, Asadullah K. (2004) The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy. Curr Drug Targets Inflamm Allergy. 3, 347-353. 

Once specific liver uptake is established, the intrahepatic distribution needs to be addressed. The importance of this issue is exemplified by the apparently high uptake of untargeted Dexa by the liver. Dexa itself was taken up exclusively by the hepatocytes, whereas targeted Dexa was taken up by SECs and KCs [152], the target cells for anti-inflammatory therapy. 

B. If replacement analgesic or anti-inflammatory therapy is required then the current options include ... 

Formoterol anti-inflammatory therapy prevention Prolongation of QTc interval... 

Bendas, G., A. Krause, R. Schmidt, J. Vogel, and U. Rothe, Selectins as new targets for immunoliposome-mediated drug delivery. A potential way of anti-inflammatory therapy. Pharm Acta Helv, 1998. 73(1) 19-26. 

The morpholinoethyl ester morniflumate, which is used in topical formulations was shown to inhibit both cyclooxygenase and 5-lipoxygenase, thus suggesting an additional potential in anti-inflammatory therapy (Civelli et al., 1991). 

Barnes PJ. 2000. New directions in allergic diseases Mechanism based anti-inflammatory therapies. J All Clin Immunol. 106 5-16. 

Skin manifestations of accompanying atopic eczema require a parallel local anti-inflammatory therapy, specifically with topic corticoids, anti-itching preparations and various fatty ointments. In the future, tacrolimus and pime-crolimus preparations might play a special role because they are able to substitute the application of corticoids [18]. 

As a consequence of the various proinflammatory properties of S100 proteins, strategies targeting these molecules by in vivo administration of S100 antibodies are a novel option for anti-inflammatory therapies. Another approach is the inhibition of the release of these cytokine-like molecules at sites of inflammation. 

Dinwiddie R. Anti-inflammatory therapy in cystic fibrosis. J Cyst Fibros. 2005 4(suppl 2) 45-48. 

Wraight JM, Smith AD, Cowan JO, et al. Adverse effects of short-acting beta-agonists potential impact when anti-inflammatory therapy is inadequate. Respirology. 2004 9 215-221. 

Zeni, F., Freeman, B., Natanson, C. Anti-inflammatory therapies to treat sepsis and septic shock A reassessment. Crit Care Med 25 (1997) 1097-1100. 

The asthma market is thought to be worth some 6 billion worldwide, and consists mainly of inhaled products—bronchodilators and corticosteroids. It is a growing market because the incidence of asthma is increasing, especially in developed countries. It has been postulated that this increase is partly related to overuse of inhaled bronchodilators, which can mask progression of the underlying inflammatory disease process. Current recommendations specify the routine use of anti-inflammatory therapy (e g. inhaled steroids) for mild asthma, with bronchodilators used to relieve acute attacks in more serious cases. 

Anti-inflammatory therapy is the more successful the less use is made of as-needed p2-mimetic medication. 

Identification of a New Therapeutic Target for Anti-Inflammatory Therapy by Analyzing Differences in the Phosphoproteome of Wild Type and Knock Out Mice... 

Obviously, MK5 is not able to compensate for this effect, making MK2 a unique pharmacological target for anti-inflammatory therapy. 

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