Deprivation experiment

Most sleep deprivation experiments have used mentally and physically healthy young adults. For other types of individuals, particularly older people for whom the sleep function deteriorates in general, and also for "real world" conditions, sleep deprivation may be more significant. 

Reduction of sensory input to a level as near zero as possible is a potent technique for inducing d-ASCs. in the fifties and early sixties, there were many sensory deprivation experiments during which the subject lay comfortably in a dark, quiet room without moving. The findings were interpreted as showing that if the brain did not receive sufficient sensory input, the subject went "crazy." it is now clear 46, 55 that practically all these studies were severely contaminated,... 

A wide variety of tests have been used in sleep deprivation experiments ranging from simple tests of reaction time (e.g., Refs. 1,2,13) to complex tasks of higher-order cognitive capacity and PFC function (e.g., Refs. 9,14,15). The diversity of performance tests available for use in performance testing leads to a fundamental question What are the criteria for an effective neurocognitive assay under conditions of sleep deprivation, where effective means theoretically meaningful, empirically sensitive, and practically useful ... 

Lagarde D, Batejat D, Van Beers P, Sarafian D, Pradella S. Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fundam Clin Pharmacol 1995 9 271-279. 

Our studies of the ERT cell cycles show that they are regulated by nutrition (Britton Edgar 1998). If the newly hatched larva is starved for dietary amino acids, DNA replication in most ERTs is not initiated. Under starvation conditions these tissues express low levels of cyclin E and E2F, the transcription factor which is probably responsible for cyclin E expression. If either E2F or cyclin E is induced in starved larvae, DNA replication in the ERTs is activated, and thus expression of these genes appears to limit the ERT cell cycle. When nutrient-deprived larvae are fed, expression of E2F and cyclin E mRNAs increases approximately sixfold, and DNA replication is initiated in most ERT cells. If the animal is first fed and then starved, the ERT cell cycle is activated and then inactivated quite rapidly. These experiments all indicate that the ERT cell cycle is nutrition-responsive, rather than controlled by a rigid developmental program. 

At about the same time as Pappenheimer s studies, another approach emerged for finding the elusive hypnotoxin. Monnier, later joined by Schoenenberger, used somnogenic electrical stimulation of the thalamus in rabbit, instead of sleep deprivation (Monnier and Hosli 1964). Cross-stimulation experiments showed that the somnogenic actions of the thalamic stimulation could be... 

The results regarding socioeconomic gradients undermines the hypothesis that the principal social class influence on health is material deprivation. In fact, the social class gradient in health cuts deeply into the affluent middle classes. The implication is that the conditions under which people live can affect human health directly, and not only through material deprivation. Early childhood experience, one s place in the social environment, and the experiences of daily life must be powerful determinants of the length and healthfulness of life (Kelly et al., 1997, p. 438). 

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