Deoxyribonucleic acid base pairs

DeoxyriboNucleic Acid Base-pair, kilobase-pair Total acrylamide content Bisacrylamide/total acrylamide content Electrophoretic mobility Electrophoretic mobility in free solvent Limiting mobility fractional volume... 

Schematic diagram of deoxyribonucleic acid (DNA) showing the pairing of nitrogen bases (A-T C-G) between parts of two strands of DNA, the backbone of each strand being composed of alternately linked sugar and phosphate units.

The discovery of the base-paired, double-helical structure of deoxyribonucleic acid (DNA) provides the theoretic framework for determining how the information coded into DNA sequences is replicated and how these sequences direct the synthesis of ribonucleic acid (RNA) and proteins. Already clinical medicine has taken advantage of many of these discoveries, and the future promises much more. For example, the biochemistry of the nucleic acids is central to an understanding of virus-induced diseases, the immune re-sponse, the mechanism of action of drugs and antibiotics, and the spectrum of inherited diseases. 

DNA (deoxyribonucleic acid) A double-stranded molecule held together by weak bonds between base pairs of nucleotides that encodes genetic information. The base sequence of each single strand can be deduced from that of its partner since base pairs form only between the bases A and T and between G and C. 

A nucleophilic attack on deoxyribonucleic acid (DNA) that causes the disruption of base pairing occurs as a result of the administration of... 

The well-known double-helical structure of DNA (deoxyribonucleic acid) is derived from the specificity of the Watson-Crick base pairing.154 Yanagawa and co-workers first addressed the issue of whether mononucleotide units could be... 

See also Deoxyribonucleic acid (DNA) base-pair sequencing of, 22 11 molecular structure of, 22 10 capillary electrophoresis, 4 636-637 chemical analysis of ancient, 5 750-751 contact print, 22 504 as a vaccine, 25 502-503... 

Deoxyribonucleic acid footprinting studies have shown that HMG domains A and B inhibit cleavage by nucleases over a 12- to 15-base-pair region centered around the platinum adduct (81). The HMG proteins can modulate cisplatin cytotoxicity by inhibition of the excinuclease-mediated removal of Pt-d(GpG) adducts from DNA (82). However, this hypothesis has been questioned because there is no evidence for cellular protein shielding of Pt-d(GpG) adducts from repair enzymes (83). 

List of Abbreviations PCR, polymerase chain reaction RT-PCR, reverse transcription polymerase chain reaction DNA, deoxyribonucleic acid RNA, ribonucleic acid RNase, ribonuclease mRNA, messenger RNA GABAa, y-aminobutyric acid type A cRNA, copy RNA dNTPs, deoxy nucleoside triphosphates MMLV, Mouse Moloney murine leukemia vims RT, reverse transcriptase bp, base pair Tm, melting temperature DEPC, diethylpyrocarbonate OD, optical density mL, milliliter SA-PMPs, streptavidin paramagnetic particles dT, deoxy thymidine DTT, dithiothreitol DNase, deoxyribonuclease RNasin, ribonuclease inhibitor UV, ultraviolet TBE, Tris-borate, 1 mM EDTA EDTA, ethylenediaminetetraacetic acid Buffer RET, guanidium thiocyanate lysis buffer PBS, phosphate buffered saline NT2, Ntera 2 neural progenitor cells... 

The nucleic acids known as deoxyribonucleic acid (DNA) are the molecules that store genetic information. This information is carried as a sequence of bases in the polymeric molecule. Remarkably, the interpretation of this sequence depends upon simple hydrogen bonding interactions between base pairs. Hydrogen bonding is fundamental to the double helix arrangement of the DNA molecule, and the translation and transcription via ribonucleic acid (RNA) of the genetic information present in the DNA molecule. 

What s DNA Deoxyribonucleic acid, the helical ladderlike chain of molecules that makes up genes. DNA consists of a sugar molecule called deoxyribose (it is somewhat related to glucose), a nitrogen-containing molecule called a base, and phosphate atoms bonded to the other two components. It is the sequence of base pairs (one base on each strand) in DNA that determines the end-product (e.g., protein). The human genome— the entire DNA content of a human being—contains approximately 3 billion base pairs. 

Density of states weighted Franck-Condon factor Deoxyribonucleic acid Barrier height for the adiabatic hole motion Difference in ionization potentials of adenine-thymine and guanine-cytosine base pairs... 

DNA (deoxyribonucleic acid) The basic genetic material found in all living cells (and some viruses), providing the blueprint (i.e. genes) for construction of proteins. DNA is composed of sugars, phosphates, and bases arranged in a double helix, a double stranded, chain-like molecules composed of nucleotide base pairs. 

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