Deoxyadenylic acid

It is noteworthy that the infected system contains the 2-deoxy-D-ri-bose nucleotides of adenine, guanine, and uridine, in contrast to the nucleotide in the normal system. It has, however, been reported that even the normal Escherichia coli cells contain 2-deoxyadenylic acid, 2-deoxy-guanylic acid, and thymidylic acid. 

Fukui, T., Kakiuchi, N. and Ikehara, M. (1982) Protein synthesis using poly(2 -halogeno-2 -deoxyadenylic acids) as messenger. Biochim. Biophys. Acta, 697, 174-177. 

In the meantime, in the formation of deoxyribonucleic add (DNA), the nudeosides 2 -deoxyadenosine and 2 -deoxyguanosine, which lack the oxygen atom at the 2 position in the sugar moieties, are utilized.These compounds are referred to as 2 -deoxyadenylic acid (dAMP) and 2 -deoxyadenylic add (dGMP), respectively. A nucleic acid is therefore a polymer of nucleotides. 

Figure 14 Fractionation of 40-60-base oligodeoxyadenylates. Column 0.41 x 5 cm column packed with cross-linked and methylated PEI on Hypersil , 3 p. Eluent 50 mM potassium phosphate, 15% acetonitrile, pH 5.9 with a gradient from 200-500 mM ammonium sulfate. Flow rate 0.5ml/min. Oligomers of deoxyadenylic acid were fractionated up to a degree of polymerization of 60.180 (Reproduced with permission of Academic Press from Drager, R. R. and Regnier, F. E., Anal. Biodiem., 145, 47, 1985.)...

Deoxyribose Deoxyadenosine Deoxyadenylic acid deoxyadenosine monophosphate (dAMP) Deoxyadenosine diphosphate (dADP) Deoxyadenosine triphosphate (dATP)... 

Adenosine 5 -phosphate is also known as AMP (for adenosine monophosphate) or adenylic acid. If deoxyribose replaces ribose in adenosine 5 -phosphate, the terminology is dAMP or deoxyadenylic acid. The abbreviated names for some ribonucleotides and deoxyribonucleotides are listed below. 

Adenine, A Adenylic acid, AMP Deoxyadenylic acid, dAMP... 

ECO RI ENDONUCLEASE. Eco RI endonuclease is one of the better studied endonucleases. It is a small protein of 276 amino acid residues (31,065 daltons) of known sequence (6,7). The active enzyme contains two subunits (8,9) and hydrolyzes the phospho-diester bond between the deoxyguanylic and deoxyadenylic acid residues of duplex 5 -GAATTC-3. On hydrolysis, there is an... 

DNA contains the bases adenine (A), thymine (T), guanine (G), and cytosine (C). These bases are covalently attached to the deoxyribose phosphate to form nucleotides. The respective nucleotides are called deoxyadenylic acid (dA), deox)hhy-midylic acid (dT), deoxyguanylic acid (dG), and deoxycytidylic add (dC). The prefix "deoxy" indicates that the sugar is deoxyribose, rather than ribose. The word "acid" indicates that the ribose contains a covalently bound phosphoric acid group. 

Using the same rationale as is used above in the purine section, it can be seen from the results in the Table that an extensive back reaction of the deoxyguanylic acid -(Cl2") radical occurs. The slight radioprotective effect of chloride in acidic solutions of deoxycytidylic acid and deoxyadenylic acid may be caused by the inability of these compounds to react with Cl2". 

Adenine A Adenylic acid AMP Deoxyadenylic acid dAMP... 

Structure of deoxyadenylic acid, the nucleotide formed from phosphoric acid, deoxyribose, and the organic base adenine. 

Fig. 8. SERS spectra of the mixed solution of 21U and poly(deoxyadenylic acid). The spectra were taken at 10 min (a) and 3 days (b) after mixing of the two components. Experimental condition wavelength 514.5 nm, power 10 mV at the sample, integration time 10 scans at 1 s/scan...

The 5 -adenyhc acid deaminase (22) found in rabbit muscle has been crystallized (23). It converts adenylic acid to inosinic acid and ammonia [Eq. (7)]. The enzyme does not deaminate adenine, adenosine, adenosine diphosphate, adenosine triphosphate, adenosine 2 -phosphate, adenosine S -phosphate, guanosine, or cytosine but does act upon deoxyadenylic acid (24)-... 

Quinacrine concentrates in the scolex of the parasite and causes the muscles needed for holding onto the intestinal wall to relax. The worms are stained yellow and pass from the body, still aUve. Quinacrine can intercalate with DNA and inhibit nucleic acid synthesis. It creates fluorescent bands in deoxyadenylate—deoxythmidylate-rich regions of DNA and has been used as a stain in the study of human genetics. 

The two types of natural polynucleotides (nucleic acids) are classified according to the sugars they contain. Ribonucleic acid (RNA) contains exclusively P-o-ribose, while the sugar in deoxyribonucleic acid (DNA) is P-2-deoxy-D-ribose. Different nucleic acids can have from around 80 nucleotides (nt), as in transfer RNA (tRNA), to over 10 nucleotide-pairs in a single eukaryotic chromosome. The unit for size of nucleic acid is the base (for single-stranded species) or the base-pair (bp, for double-stranded species), with the unit Kb (thousand base-pairs) and Mb (million base-pairs). Examples of synthetic homopolynucleotides are poly(uridylate) or poly(deoxyadenylate), in poly(U) or poly(dA)... 

Deoxyribonucleotides Monomeric units of DNA, including deoxyadenylic (dAMP), deoxyguanylic (dGMP), deoxycytidylic (dCMP), and deoxythymidylic (dTMP) acids. 

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