Dendritic glycopolymers

AF4 coupled with static and DLS detectors enables comprehensive information about structural and branching characteristics of biopolymers (e.g., starches), synthetic polymers, proteins, etc. [25, 26]. Especially in case of branched polymer stractures like dendronized glycopolymers, the separation and characterization with AF4-LS lead to comprehensive information and understanding in molecular structures and aggregation behavior [27]. Furthermore, studies of uptake studies of dendritic glycopolymers and dye molecules were performed for the first time by AF4-LS (see Fig. 4.12). Here, a good correlation was obtained between the increase of molar mass and the quantified amount of dye molecules, which were encapsulated by the glycopolymers [28]. 

FIGURE 6.7 Schematic illustration of the constructed pH-sensitive polymeric capsule with a dendritic glycopolymer inside the core and the formation of a porous wall by switching the pH to 6 or lower, which can lead to the release of the encapsulated dendritic glycopolymer tuned by the shear rate [9] (for TEM images of collapsed and swollen membrane, cf. Fig. 4.13). Source Gaitzsch et al. [9], figure 1. Reproduced with permission of John Wiley Sons. 

In studies on selectin inhibition with functionalized dendritic glycopolymers (Fig. 6.24), Papp et al. were able to demonstrate with a competitive SPR-based measurement system that galactose acts as a minimal selectin ligand, if available in sufficient concentration [104]. Compared to a tetravalent architecture... 

Synthetic glycopolymers of various architectures have been prepared in recent years using the fast development of controlled polymerization techniques and the very efficient coupling reactions in polymer analogous approaches. Both, linear and globular polymer structures that have been obtained by synthesizing dendritic, starlike, or micelle-like structures or nanogels have received much attention. 

Relatively simple mannose-containing glycopolymers can effectively bind to human dendritic cell-associated lectin (DC-SIGN) and disrupted the interaction of DC-SIGN interactions with HIV envelope glycoprotein gpl20, which could be seen as a new therapeutic approach (Fig. 15) [80]. 

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