Dendritic cells results

Vink, A. A. et al., The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers, Proc. Natl. Acad, Sci. USA 94, 5255-5260, 1997. 

Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 2001 108 1865-1873. 

T cells only respond to protein antigens when the antigen has been processed by the APCs. The resultant small peptide molecules are then bound to the Class 2 molecules on the surface of the APCs. Monocytes, macrophages, B cells, dendritic cells and some... 

FIGURE 9.2 Regulation of Immunity by lnterleukin-2 (IL-2). IL-2 production by T cells and DCs supports the proliferation of T cells, B cells, T reg cells, and NK cells, in addition to establishing a bias towards a Type 1 T cell response. IL-2 can also activate monocytes and NK cells, resulting in increased cytotoxicity. DC dendritic cell IL-2 interleukin-2 NK natural killer cell. 

Histamine induces intracellular Ca " flux, actin polymerization, and chemotaxis in immature DCs due to stimulation of HRl and HR3 subtypes. Maturation of DCs results in loss of these responses. In maturing DCs, however, histamine dose-dependently enhances intracellular cAMP levels and stimulates IL-10 secretion, while inhibiting production of IL-12 via HR2 [16]. Interestingly, although human monocyte-derived dendritic cells have both histamine Hj and H2 receptors and can induce CD86 expression by histamine, human epidermal Langerhans cells express neither H nor Hj receptors [72]. 

With regard to surface molecule expression of keratinocytes and their role in immunoregulation, a recent study by Loser et al. [49] showed that the member of the TNF superfamily, RANKL, is expressed on keratinocytes of inflamed human and mouse skin. In a murine system, RANKL overexpression in keratinocytes resulted in functional alterations of epidermal dendritic cells and systemic... 

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