Demodex

Detection and identification of Helicobacter pylori and Demodex folliculorum (Fig. 17.13). [Pg.191]

Topical metronidazole is effective in the treatment of rosacea. The mechanism of action is unknown, but it may relate to the inhibitory effects of metronidazole on Demodex brevis alternately, the drug may act as an anti-inflammatory agent by direct effect on neutrophil cellular function. Oral metronidazole has been shown to be a carcinogen in susceptible rodent species, and topical use during pregnancy and by nursing mothers and children is therefore not recommended. [Pg.1288]

Demodicosis is thought to be caused by an over-infestation of the mite in the follicles and pilosebaceous glands of the eyelids. These parasites cause destruction of the epithelial and glandular tissue, producing follicular distension, hyperplasia, increased keratinization, and acute inflammation. Dead mites and keratinization may play a role in the stagnation of secretions, which adds to the overall disease process. No current studies adequately prove the minimum number of mites necessary to produce symptoms therefore their role in pathogenesis remains imclear. It has been postulated that Demodex... [Pg.397]

Figure 23-19 (A-C) Cylindrical sleeves (arrows) that rest on the lid margin as seen in Demodex blepharitis. (Gao Y, Pascuale MA, Li W, et al. High prevalence of Demodex in eyelashes with cylindrical dandruff, Invest Ophthalmol Vis Sci 2005 46 3089-3094).

Arici MK, Sumer Z,Toker, MI, et al.The prevalence of Demodex fotticulorum in blepharitis patients and the normal population. Ophthalmic Epidemiol 2005 12 287-290. [Pg.414]

Rosacea has characteristic clinical findings. These include an acneiform papular-pustular eruption associated with erythema and hypertrophic sebaceous glands. Typically, these changes appear on the cheeks, nose, and forehead, known as the fecial flush areas. The frontal area of the chest may also be involved. Infestation and possible inflammation caused by the hair follicle mites Demodex folUculorum and Demodex brevis have been linked to rosacea. Rosacea has no known relationship to previous juvenile acne. [Pg.463]

Amitrazb Sarcoptes, Demodex Liquid concentrate (sponge on)... [Pg.193]

Demodexfolliculorum would be more common in pap-ulopustular [10, 11] and steroid rosacea [5, 14], In 1981, Rufli et al. [13] observed that mite prevalence increases with the age and that the search for the mite is positive in almost 100% of elderly healthy subjects. These results were confirmed in a study by Crawford et al. [16], who stated that Demodex is found in a large number of healthy persons. In fact, with modem and sensitive techniques, the prevalence in healthy adults approaches 100%. Consequently, the simple identification of Demodex is by no means proof of pathogenesis. Furthermore, at least four studies [13,14,17,18] clearly demonstrated that specific therapies, both topical and systemic, Against Demodex folliculorum do not reduce the amount of the mite, but they improve the disease according to the chnical point of view. On the basis of the results of all these studies, the search for Demodexfolliculorum in a patient with rosacea is neither necessary nor helpful for therapy. [Pg.160]

Five percent permethrin significantly reduces the burden of Demodex folliculorum in the skin of patients with rosacea. Its efficacy is similar to that of 0.75% metronidazole gel [49, 50]. Also 10% crotamitone seems to be effective in papulopustular rosacea [51],... [Pg.162]

Ayres S Jr (1988) Acne rosacea in blacks - were Demodex mites found in any patients J Am Acad Dermatol 18 387-388... [Pg.163]

Sibenge S, Gawkrodger DJ (1992) Rosacea a study of clinical patterns, blood flow, and the role of Demodex folliculo-rum. J Am Acad Dermatol 26 590-593... [Pg.163]

Liibbe J, Stucky L, Saurat JH (2003) Rosaceiform dermatitis with follicular Demodex after treatment of facial atopic dermatitis with 1% pimecrohmus cream. Dermatology 207 205-207... [Pg.163]

Kaufmann-Wolf M (1925) Uber regelmassiges vorkommen von Demodex folliculorum in den pusteln von rosacea pustu-losa. Derm Wschr 81 1095-1103... [Pg.163]

Forton F, Seys B (1993) Density of Demodex folliculorum m rosacea a case-control study using standardized skin-surface biopsy. Br J Dermatol 128 650-659... [Pg.163]

Roihu T, Kariniemi AL (1998) Demodex mites in acne rosacea. J Cutan Pathol 25 550-552... [Pg.163]

Rufli T, Mumcuoglu Y, Cajacob A, Buchner S (1981) Demodex folliculorum. zur atiopathogenese und therapie der rosazea und der perioralen dermatitis. Dennatologica 162 12-26... [Pg.163]

Bonnar E, Eustace P, Powell FC (1993) The Demodex mite population in rosacea. J Am Acad Dermatol 28 443 48... [Pg.163]

Erbagci Z, Ozgozta i O (1998) The significance of Demodex folliculorum density in rosacea. Int J Dermatol 37 421 25... [Pg.163]

Robinson TWE (1965) Demodex folliculorum and rosacea. A clinical and histological study. Arch Dermatol 92 542-544... [Pg.163]

Demodex mites has been observed in abundance in patients with flares of rosacea during topical treatment with tacrolimus and pimecrolimus it is possible that treatment... [Pg.338]

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