Rosacea Demodex folliculorum

Demodexfolliculorum would be more common in pap-ulopustular [10, 11] and steroid rosacea [5, 14], In 1981, Rufli et al. [13] observed that mite prevalence increases with the age and that the search for the mite is positive in almost 100% of elderly healthy subjects. These results were confirmed in a study by Crawford et al. [16], who stated that Demodex is found in a large number of healthy persons. In fact, with modem and sensitive techniques, the prevalence in healthy adults approaches 100%. Consequently, the simple identification of Demodex is by no means proof of pathogenesis. Furthermore, at least four studies [13,14,17,18] clearly demonstrated that specific therapies, both topical and systemic, Against Demodex folliculorum do not reduce the amount of the mite, but they improve the disease according to the chnical point of view. On the basis of the results of all these studies, the search for Demodexfolliculorum in a patient with rosacea is neither necessary nor helpful for therapy. 

Five percent permethrin significantly reduces the burden of Demodex folliculorum in the skin of patients with rosacea. Its efficacy is similar to that of 0.75% metronidazole gel [49, 50]. Also 10% crotamitone seems to be effective in papulopustular rosacea [51],... 

Kaufmann-Wolf M (1925) Uber regelmassiges vorkommen von Demodex folliculorum in den pusteln von rosacea pustu-losa. Derm Wschr 81 1095-1103... 

Forton F, Seys B (1993) Density of Demodex folliculorum m rosacea a case-control study using standardized skin-surface biopsy. Br J Dermatol 128 650-659... 

Erbagci Z, Ozgozta i O (1998) The significance of Demodex folliculorum density in rosacea. Int J Dermatol 37 421 25... 

Robinson TWE (1965) Demodex folliculorum and rosacea. A clinical and histological study. Arch Dermatol 92 542-544... 

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