Delivery systems bioadhesivity

V. Lenaerts and R. Gumy, eds.. Bioadhesive Drug Delivery Systems, CRC Press, Inc., Boca Raton, Fla., 1990. 

Bioadhesive Drug Delivery Systems Fundamentals, Novel Approaches, and Development, edited by Edith Mathiowitz, Donald E. Chickering III, and Claus-Michael Lehr... 

In the gastrointestinal tract, a mucoadhesive drug delivery system provides advantages in prolonging the residence time of devices. The use of pH-sensitive bioadhesive polymers has been proposed [26], An extensive review of pH-sensi-tive hydrogels is given by Brpndsted and Kopecek [27],... 

PK Gupta, S-H Leung, JR Robinson. Bioadhesive/mucoadhesives in drug delivery to the gastrointestinal tract. In V Lenaerts, R Gurny, eds. Bioadhesive Drug Delivery Systems. Boca Raton, FL CRC Press, 1990, pp 65-92. 

Binodal curves, 20 320-321 Bins concept, 70 32 Bioaccumulation, of herbicides, 73 310 Bioactive barrier, defined, 3 758t Bioactive fixation, 72 611 Bioactive food ingredients, 7 7 646 Bioactive nutritions, 7 7 645t Bioactive substances identifying, 77 646 safety of, 77 647 Bioactive zone, defined, 3 758t Bioadhesive agents, 9 48, 49 Bioadhesive drug delivery systems, 9 45... 

M. Singh, M. Briones, and D. T. O Hagan. A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J Control Release 70 267-276 (2001). 

An interesting feature of current commercial products is that the polymer vehicles available for formulation have been limited to nonionic and anionic materials. The delivery vehicles available included off-the-shelf polymers such as carboxymethylcellulose, soluble starch, hydroxyethyl-cellulose, polyvinyl alcohol, poly(acrylic acid), and polyvinylpyrrolidone, or mixtures thereof. The choice of available polymeric delivery system primarily depends on component compatibility, aesthetics, and efficacy. However, by reliance upon available (off-the-shelf) systems, limitations on bioadhesion, drug bioavailability, contraceptive efficacy, and end-use characteristics has been limited. 

Campbell, B.J., Biochemical and Functional Aspects of Mucus and Mucin-type Glycoproteins. In Bioadhesive Drug Delivery Systems (E. Mathiowitz, D.E. Chickering, lit, and C.-M. Lehr, eds.) Marcel Dekker, Inc., New York, 1999, pp. 85-130. 

Ilium, L., Jorgensen, H., Bisgaard, H., Krogsgaard, O., and Rossing, N., Bioadhesive microspheres as a potential nasal drug delivery system, Int. J. Pharm., 39 189-199 (1987). 

The most potent mucosal adjuvants have been shown to be the toxins derived from Vibrio cholerae or Escherichia coli, which should not be surprising since these organisms invade the body through the GI tract. Obviously too toxic for human use because they are the source of cholera or diarrhoea, heat labile enterotoxins have been tested in mice and shown to be potent adjuvants for orally or nasally administered influenza vaccine. The potency of heat-labile enterotoxin mutants may also be enhanced by formulation into bioadhesive particulate delivery systems, and this is an area under current exploration. 

Nielsen, L. S. 1998. A bioadhesive drug delivery system based on liquid cr fSTsInt. Appl.176 pp. 

Bioadhesive Sustained- and Controlled-Release Drug Delivery Systems. 628... 

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