Bioadhesive delivery systems films

Mucoadhesive Polymers Bioadhesion refers to the attachment of a drug molecule or a delivery system to a specific biological tissue by means of interfacial forces. If the surface of the tissue is covered by a mucin film, as is the case for the external globe, it is more commonly referred to as mucoadhesion. 

There is also increasing interest in the per-acyl-CDs. All acetylated CDs from per-acetyl to per-octanoyl esters were studied partly as retard drug carriers (to retard the drug release for absorption from its pharmaceutical formulation). partly as bioadhesive, film-forming substances to be used in transdermal drug delivery systems. 

A bioadhesive hot-melt extruded film for intraoral drug delivery and the processing thereof has been patented.f Applications of these films may be utilized in transmucosal drug delivery or even transder-mal systems. The films may be produced separately and layered after extrusion, or in some cases, a multilayered system may be extruded in one continuous process. Currently on the market is an extruded film device that is utilized as a denture adhesive. This system includes thermoplastic polymers that have a bioadhesive quality when the film is wetted. Before application and wetting, however, this thin film may be held in one s hand and shaped or cut. This device is again produced by a one-step, continuous process using hot-melt extrusion technology. 

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