Dehydrogenases isocitrate dehydrogenase

Figure 22-4. Sequence of reactions in the oxidation of unsaturated fatty acids, eg, linoleic acid. A -c/s-fatty acids or fatty acids forming A -c/s-enoyl-CoA enter the pathway at the position shown. NADPH for the dienoyl-CoA reductase step is supplied by intramitochondrial sources such as glutamate dehydrogenase, isocitrate dehydrogenase,and NAD(P)H transhydrogenase.

K8. Kerppola, W., Nikkila, E. A., and Pitkanen, E., Serum TPN linked enzymes glucose-6-phosphate dehydrogenase, isocitric dehydrogenase and glutathione reductase activities in health and various disease states. Acta Med. Scand. 164, 357-305 (1959). 

HYDROXYSTEROID DEHYDROGENASES ISOCITRATE DEHYDROGENASE B-KETOACYL-ACP REDUCTASE... 

Enzymes (malate dehydrogenase, lactate dehydrogenase, isocitrate dehydrogenase, citrate lyase)... 

NADH is produced by the a-ketoglutarate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase reactions of the TCA cycle, by the pyruvate dehydrogenase reaction that converts pyruvate to acetyl CoA, by (3-oxidation of fatty acids, and by other oxidation reactions. 

Two turns of the TCA cycle, with NADH produced at the pyruvate dehydrogenase, isocitrate dehydrogenase, alpha-ketoglutarate, and malate dehydrogenase steps and FADH2 produced at the succinate dehydrogenase step and GTP (equivalent to ATP) produced at the succinyl-coenzyme A synthetase step. 

Glutamate dehydrogenase Isocitrate dehydrogenase Ketogenesis enzymes Malate dehydrogenase Ornithine transcarbamylase Pyruvate carboxylase... 

Thus an increase in intramitochondrial Ca concentration in the range 0-10 m causes the coordinate activation of the three Ca -sensitive enzymes, pyruvate dehydrogenase, isocitrate dehydrogenase and oxoglutarate dehydrogenase with a consequent activation of the citrate cycle. 

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