Deaeration Equipment Design Evaluation

Pilot compaction trials were conducted to investigate the vacuum deaeration effect when compacting an antibiotic powder with 0.2g/cm density. The 

Note Slugging parameters 4 ton pressure, 0.75 in flat faced tooling, slug weight = 0.8-1.Ogr, slug hardness, = 12-18 Strong Cobb units, sized through oscillator 16 mesh screen. 

Study determined the compact throughput, compact density, and fines (not compacted during vacuum deaeration) when using a new equipment feed system design. The parameters controlled and monitored during the compaction process were vacuum deaeration pressure, roll pressure, roll and screw speeds, room temperature, and humidity. 

The equipment feed design consisted of a funnel-shaped powder hopper (with no vacuum deaeration system) that was located directly above the rolls. The powder hopper was retrofitted with vacuum deaeration capability. A high compression feed screw, fitted inside the funnel hopper, fed the powder directly into knurled rolls. The compaction trials were conducted with and without vacuum deaeration. The compact was carefully collected directly on a 10-mesh screen. Powder particles, that were not compacted (i.e., those particles which were not attached to the compact, for example, fines bypassing roll compaction and the non-adhering compacted powder particles) were weighed and separated. The compact was not milled. The parameters are noted in Table 4. 

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Miller s experiments evaluated the effects of powder density screw feed speed, roll speed, roll pressure, vacuum deaeration pressure, compaction rate, and the compaction leakage rate. Test results demonstrated that the first compactor s deaeration and feed system designs significantly increased compaction output. The new equip-... 

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