Database safety data

Hazardous Substances Data Bank (HSDB) on compact disc from the Canadian Center for Occupational Health and Safety (can buy at CCOHS web site). "The HSDB(R) (Hazardous Substances Data Bank(R)) database contains data profiles on 4,500 potentially toxic chemical substances. It is created and updated by specialists at the U.S. National Library of Medicine. Compiled from an extensive range of authoritative sources, HSDB is widely recognized as a reliable and practical source of health and safety information. Much of the data is peer reviewed. 

Reconfiguration of Data. Drug safety data from different sources are often pooled or combined in databases. Reasons for combining data vary. In the case of premarketing studies, data from different sites are routinely combined because one site may not be able to recruit enough patients for a study. Data from different studies are often combined to increase sample size and therefore statistical power for detecting an uncommon adverse event. 

ChemAdvisor and the List Of Lists. ChemAdvisor and the LOLI (List Of Lists) Database contains over 2700 regulatory lists from around the world, including environmental, health and safety, international, inventories, and reference material necessary for Material Safety Data Sheet preparation. ... 

MSDS is a comprehensive database of more than 310 000 Material Safety Data Sheets, obtained directly from 2000 North American manufacturers and supphers. 

C L (Classification and Labelling), Risk and Safety Phrases, Danger and so on lUCLID (International Uniform ChemicaL Information Database) Chemical Data Sheets, lUCLID Export Files, OECD-IUCLID Export Files, FUSES Export Files... 

IUCLID International Chemical Information Database SAR SDS Structure-activity relationships Safety data sheet... 

With the increase in licensing agreements between pharmaceutical companies, safety data frequently needs to be exchanged between one or more parties. If the case volume is sufficient, it is worth considering electronic data exchange between the databases involved. In addition to preventing rekeying of data, this minimizes discrepancies between the data sets. With the adoption of proposed ICH standards in the future, this will become a much simpler process. 

To simplify the process, it is important that a single database is developed for the whole programme. This is particularly relevant to the production of safety data, not only in the interests of efficiency but also so that any safety issues will be recognised as they arise. If a particular set of adverse events is suggested by preclinical toxicology then they should be flagged in the database so that the monitors attention is drawn to them. 

Bate A, Edwards IR, Edwards J, Swahn E, Noren GN, Lindquist M. Abstracts of the 2004 ISoP annual conference knowledge finding in IMS disease analyser (Mediplus) UK database - effective data mining in longitudinal patient safety data. Drug Saf 2004 27(12) 917-8. 

Some authors have questioned whether there is sufficient efficacy and safety data to support widespread use of the a2-adrenergic agonists (Cantwell et al., 1997), a position which intensified following the report of several sudden deaths of children who were medicated with clonidine and methylphenidate in combination (Popper, 1995). Although the FDA could not establish a causal link between the medications and these catastrophic outcomes, clearly more research is needed. At the same time, interest at the national level in establishing a more extensive scientific database to support the use of previously off-label prescription patterns, and interest on the part of industry to obtain FDA approval for new indications, suggests that larger... 

A single repository for pollution prevention, compUance assurance, and enforcement information databases has the database umbrella architecture for solvent alternatives solvent substitution data systems Integrated Solvent Substitution Data System (ISSDS) Hazardous Solvent Substitution Data System on-line product information, material safety data sheets... 

In a recent article, the FDA stated For excipients with a history of use, it may be possible to adequately address some or all of the safety issues through citation of the existing nonclinical and clinical database, marketing history, or regulatory status of the compound (e.g., GRAS status as a direct food additive may adequately support oral administration of that compound up to the levels permitted in foods) (25). Therefore, it appears reasonable that the FDA would consider the use safety data based on the food additive regulatory status of an excipient to evaluate the safety of the excipient. If a new excipient has undergone a food additive safety review, this may reduce the perceived risks associated with the development and use of a new excipient. 

There are many different sources for safety data, such as Material Safety Data Sheet (MSDS), databases [13, 14], company databases, and reports. Great care is required, when using MSDS, since experience has shown that they are not always reliable. 

Material Safety Data Sheets (MSDS) Databases www.msdssearch.com/DB LinksN.htm... 

Several databases deal with classifications and with safety data sheets, as a simple search on the Internet will reveal. However, there is no internationally coordinated database. An extensive listing of safety data sheet sites is available (MSDSonline 2009). A major challenge is to make all of this information available in the languages of the users. 

You can also find specific guidelines for the safe storage, use, and disposal of thousands of types of chemical products in the Material Safety Data Sheets (MSDS). Start with http //www.ilpi.com/msds/Mntcrnct. This site links to dozens of free searchable databases, including those of top American and European universities. 

Menu-driven software to search database of chemical products in the catalog. On CD-ROM for PCs. Material Safety Data Sheets on CD-ROM. 

The BIDS RSC service provides access to four bibliographic databases and a further two databases (Chemical Safety Data Sheets and the UK Nutrient Databank via the WWW at http //www.bids.ac.uk/websearch.html) are supported by The Royal Society of Chemistry (URL http //www.bids.ac.uk/ Tfedocs/rsc.html). The databases are ... 

In contrast, the Chemical Safety Data Sheet database is searched using chemical name or synonyms, while the UK Nutrient databank is searched by food name. 

Text extracts from the following databases Analytical Abstracts, Chemical Business NewsBase, Chemical Safety NewsBase, Mass Spectrometry Bulletin, Chemical Safety Data Sheets and Chromatography Abstracts in Chapter 36, Internet resources for chemistry , reproduced by kind permission of The Royal Society of Chemistry. 

Suppliers should also periodically review the information on which the label and safety data sheet for a substance or mixture is based, even if no new and significant information has been provided to them in respect of that substance or mixture. This will require e.g. a search of chemical hazard databases for new information. The competent authority may choose to specify a time (typically 3-5 years) from the date of original preparation, within which suppliers should review the labels and SDS information. 

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