Dapsone interaction

A probable warfarin and dapsone interaction was also reported in a case study of a 41-year-old woman who exhibited a supratherapeutic INR when taking clindamycin and dapsone for an infection on her right foot. An interaction between warfarin and dapsone was identified using Lexi-Comp, and it is hypothesized that warfarin and dapsone may compete for binding on the CYP2C9 and CYP3A4 isozymes, resulting in serum elevation of warfarin levels [lO ]. 

Truong T, Haley J. Probable warfarin and dapsone interaction. Ctin Appl Thromb Hemost January-Feburary, 2012 18(l) 107-9. http / /dx.doi. org/10.1177/1076029611418963. Epub 2011 Sep 2. 

Drugs that may interact with zalcitabine include antacids, chloramphenicol, cisplatin, dapsone, didanosine, disulfiram, ethionamide, glutethimide, gold, hydralazine, iodoquinol, isoniazid, metronidazole, nitrofurantoin, phenytoin, ribavirin, vincristine, cimetidine, metoclopramide, amphotericin, aminoglycosides, foscarnet, antiretroviral nucleoside analogs, pentamidine, and probenecid. 

Deravirdine (Rescnptor) [Antiretroviral/NNRTI] Uses HIV Infxn Action Nonnucleoside RT inhibitor Dose 400 mg PO tid Caution [C, ] CDC recommends HIV-infected mothers not to breast-feed (transmission risk) w/ renal/hepatic impair Contra Use w/ drugs dependent on CYP3A for clearance (Table VI-8) Disp Tabs SE Fat redistribution, immune reconstitution synd, HA, fatigue, rash, T transaminases, N/V/D Interactions T Effects W/ fluoxetine T effects OF benzodiazepines, cisapride, clarithromycin, dapsone, ergotamine, indinavir, lovastatin, midazolam, nifedipine, quinidine, ritonavir, simvastatin, terfena-dine, triazolam, warfarin effects W/ antacids, barbiturates, carbamazepine, cimetidine, famotidine, lansoprazole, nizatidine, phenobarbital, phenytoin, ranitidine, rifabutin, rifampin effects OF didanosine EMS Use of benzodiazepines and CCBs should be avoided may cause a widespread rash located on upper body and arms OD May cause an extension of nl SEs symptomatic and supportive Deferasirox (Exjade) [Iron Chelator] Uses Chronic iron overload d/t transfusion in pts >2 y Action Oral iron chelator Dose Initial 20 mg/kg... 

Buffering agents that are compounded with didanosine to counteract its degradation by gastric acid may interfere with the absorption of other drugs that require acidity (e.g., indinavir, delavirdine, ketoconazole, fluoroquinolones, tetracyclines, dapsone). An enteric-coated formulation Videx EC) that dissolves in the basic pH of the small intestine is not susceptible to these interactions. Ganciclovir and valganciclovir can increase blood levels of didanosine. The use of zalcitabine with didanosine is not recommended because that combination carries an additive risk of peripheral neuropathy. The combination of didanosine with stavudine increases the risk of pancreatitis, hepatotoxicity, and peripheral neuropa-... 

Reverse micelles can also act as a convenient membrane mimetic medium for studying membrane interactions of bioactive peptides [329,330]. Fluorescence behavior of piroxicam in AOT-RMs and Triton X-100 microemulsions was investigated by Andrade and Costa [331].Dutta etal. [332] studied the interactions of an antileprotic drug dapson in dipalmitoyl phosphotidyl choline (DPPC)-RMs in chloroform. The DPPC was found to form RMs just beyond 6 mmol 1" concentration, which is relatively low compared to conventional AOT concentration. 

Drug Interactions Zidovudine Probenecid Imipenem-cilastatin Dapsone Pentamidine Flucytosine Vincristine Vinblastine Adriamycin Amphotericin B TMP-SMX Other nucleoside analogues... 

Critical to the success of this screening approach is the selection and use of probe substrates that have a specific metabolic pathway mediated by a single CYP. An example of specific CYP probe substrates initially studied by Dear and co-workers (Ayrton et al., 1998a) is shown in Table 6.9. Many laboratories conduct detailed validation of CYP probe substrates to determine whether they can be simultaneously administered without metabolic interaction. One metabolic cocktail consists of the probe drugs caffeine, chlorzoxazone, dapsone, debrisoquin, and mephenytoin and is referred to as the Pittsburgh cocktail (Frye et al., 1997). The use of LC/MS/MS allows for the rapid... 

Interactions. Rifampicin is a powerful enzyme inducer and speeds the metabolism of numerous drugs, including warfarin, steroid contraceptives, narcotic analgesics, oral antidiabetic agents, phenytoin and dapsone. Appropriate increase in dosage, and alternative methods of contraception, are required to compensate for increased drug metabolism (see also paracetamol overdose, p. 287). 

Mathur A, Venkatesan K, Girdhar BK, Bharadwaj VP, Girdhar A, Bagga AK. A study of drug interactions in leprosy—1. Effect of simultaneous administration of prothionamide on metabolic disposition of rifampicin and dapsone. Lepr Rev 1986 57(l) 33-7. 

The interaction of rifampicin with dapsone has been reviewed (105). In seven patients with leprosy, rifampicin shortened the half-hfe of dapsone by 50% (116). 

Lee BL, Safrin S, Makrides V, Gambertogho JG. Zidovudine, trimethoprim, and dapsone pharmacokinetic interactions in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother 1996 40(5) 1231-6. 

Lee BL, Medina 1, Benowitz NL, Jacob P, 3rd, Wofsy CB, Mills Jt. Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions. Annals of internal medicine. 1989 Apr 15 110(8) 606-n. 

Clinically important, potentially hazardous interactions with acitretin, antacids, cholestyramine, dapsone, furazolidone, halofantrine, hydroxychloroquine, methotrexate, methoxsalen, mivacurium, nilotinib, penicillamine, sulfonamides... 

Clinically important, potentially hazardous interactions with acetaminophen, ciprofloxacin, corticosteroids, dapsone, itraconazole, ketoconazole, lomefloxacin, sulfones, tenofovir, tetracycline... 

Clinically important, potentially hazardous interactions with amphetamines, benzphetamine, chloroquine, dapsone, dobutamine, dopamine, ephedrine, epinephrine, meperidine, morphine, phenylephrine, phenylpropanolamine, pseudoephedrine, sympathomimetics... 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Clinically important, potentially hazardous interactions with dapsone... 

Clinically important, potentially hazardous interactions with amiodarone, anisindione, anticoagulants, azithromycin, corticosteroids, cyclosporine, dapsone, delavirdine, dicumarol, fosamprenavir, lapatinib, lopinavir, midazolam, oral contraceptives, ritonavir, solifenacin, tacrolimus, temsirolimus, tolvaptan, voriconazole... 

Clinically important, potentially hazardous interactions with amiodarone, amprenavir, anisindione, antacids, anticoagulants, aprepitant, atazanavir, atovaquone, beclomethasone, buprenorphine, corticosteroids, cortisone, cyclosporine, cyproterone, dabigatran, dapsone, darunavir, delavirdine, dexamethasone, dicumarol, digoxin, eszopiclone, flunisolide, fosamprenavir, gadoxetate, gestrinone, halothane, imatinib, isoniazid, itraconazole, ketoconazole, lapatinib, lorcainide, methylprednisolone, midazolam, nelfinavir, nifedipine, oral contraceptives, phenylbutazone, prednisone, protease inhibitors, pyrazinamide, ramelteon, ritonavir, saquinavir, solifenacin, sunitinib, tacrolimus, telithromycin, temsirolimus, tipranavir, tolvaptan, trabectedin, triamcinolone, triazolam, voriconazole, warfarin, zaleplon... 

Clinically important, potentially hazardous interactions with aluminium hydroxide, antacids, charcoal, cholestyramine, colestimide, colestipol, cyclosporine, cytochrome P4503A substrates, dapsone, estrogenic hormones, nitrendipine, oral contraceptives... 

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